@article{oai:shiga-med.repo.nii.ac.jp:00003941,
 author = {井上, 明星 and 新田, 哲久 and 今井, 勇伍 and 高木, 海 and 大田, 信一 and 向所, 賢一 and 渡邉, 嘉之 and INOUE, Akitoshi and NITTA, Norihisa and IMAI, Yugo and TAKAKI, Kai and TAKAHASHI, Hiroaki and OTA, Shinichi and MUKAISHO, Ken-ichi and WATANABE, Yoshiyuki},
 journal = {Cardiovascular and interventional radiology},
 month = {Jul},
 note = {Purpose: 
This animal experimental study evaluated how hepatic artery and portal vein transient occlusion affects the ablation zone of hepatic radiofrequency ablation (RFA). 

Material and methods:
Twenty-one rabbits were divided into three groups of seven each: (1) control, (2) hepatic artery occlusion, and (3) portal vein occlusion by a balloon catheter. For each rabbit, two or three RFA sessions were performed using an electrode needle. Ablation time, temperature around the tip of RFA needle at the end of RFA, ablation volume on fat-suppressed T1-weighted image in the hepatobiliary phase, and coagulative necrosis area on histopathology were measured and compared between the three groups using the Kruskal-Wallis paired Mann-Whitney U tests. 

Results:
In 43 RFA sessions (group 1, 15; group 2, 14; group 3, 14), mean tissue temperature in group 3 (77.0 °C ± 7.7 °C) was significantly higher compared to groups 1 (59.2 °C ± 18.8 °C; P = 0.010) and 2 (67.5 °C ± 9.9 °C; P = 0.010). In addition, mean ablation volume and coagulative necrosis in group 3 (2.10 ± 1.37 mm3 and 0.86 ± 0.28 mm2, respectively) were larger compared to groups 1 (0.84 ± 0.30 mm3; P < 0.001 and 0.55 ± 0.26 mm2; P = 0.020, respectively) and 2 (0.89 ± 0.59 mm3; P = 0.002 and 0.60 ± 0.22 mm2; P = 0.024, respectively). 

Conclusion:
Portal vein occlusion potentially boosts tissue temperature, ablation volume, and area of histopathologically proven coagulative necrosis during hepatic RFA in the non-cirrhotic liver.},
 title = {Effect of Portal Vein and Hepatic Artery Occlusion on Radiofrequency Ablation : Animal Experiment Comparing MR and Histology Measurements of the Ablation Zones.},
 year = {2021}
}