@article{oai:shiga-med.repo.nii.ac.jp:00003935,
 author = {藤吉, 朗 and 久松, 隆史 and 門田, 文 and 瀬川, 裕佳 and 近藤, 慶子 and 鳥居, さゆ希 and 中川, 義久 and 鈴木, 友彰 and 浅井, 徹 and 三浦, 克之 and 上島, 弘嗣 and VU, Thien and FUJIYOSHI, Akira and HISAMATSU, Takashi and KADOTA, Aya and ZAID, Maryam and SEGAWA, Hiroyoshi and KONDO, Keiko and TORII, Sayuki and NAKAGAWA, Yoshihisa and SUZUKI, Tomoaki and ASAI, Tohru and MIURA, Katsuyuki and UESHIMA, Hirotsugu},
 issue = {7},
 journal = {Circulation journal : official journal of the Japanese Circulation Society},
 month = {Jun},
 note = {pdf, Background:
Risk factors for atherosclerotic disease including dyslipidemia have been shown to be associated with aortic valve calcification (AVC). Nuclear magnetic resonance (NMR)-measured lipoprotein particles, low-density and high-density lipoprotein particles (LDL-p, HDL-p) in particular, have emerged as novel markers of atherosclerotic disease; however, whether NMR-measured particles are associated with AVC remains to be determined. This study aimed to examine the association between NMR-based lipoprotein particle measurements and standard lipids with AVC. The primary variables of interest were LDL-p (nmol/L), HDL-p (μmol/L), LDL-cholesterol, and HDL-cholesterol (both in mg/dL).Methods and Results:A community-based random sample of Japanese men aged 40-79 years examined in 2006-2008, in Shiga, Japan was studied. Presence of AVC was defined as an Agatston score >0. Lipoprotein particles were measured using NMR spectroscopy. In the main analysis, multivariable-adjusted odds ratios (ORs) and 95% confidence intervals (95% CIs) for the prevalence of AVC across the higher quartiles of lipids in reference to the lowest ones were obtained. Of 874 participants analyzed, 153 men had AVC. Multivariable-adjusted ORs of prevalent AVC for the highest vs. the lowest quartile were significantly elevated for LDL-p (OR, 2.20; 95% CI: 1.23-3.93) and LDL-cholesterol (OR, 2.16; 95% CI: 1.23-3.78). In contrast, neither HDL-p nor HDL-cholesterol was associated with AVC., Conclusions:
The association of prevalent AVC with NMR-based LDL-p was comparable to that with LDL-cholesterol., Journal Article},
 pages = {1076--1082},
 title = {Lipoprotein Particle Profiles Compared With Standard Lipids in the Association With Subclinical Aortic Valve Calcification in Apparently Healthy Japanese Men.},
 volume = {85},
 year = {2021}
}