@article{oai:shiga-med.repo.nii.ac.jp:00003869,
 author = {青木, 健 and 永谷, 幸裕 and 野間, 和夫 and 津川, 拓也 and 河野, 直明 and 木田, 友佳子 and 原田, 直樹 and 田上, 佳英 and 渡邉, 嘉之 and AOKI, Ken and NAGATANI, Yukihiro and NOMA, Kazuo and TSUGAWA, Takuya and KONO, Naoaki and KIDA, Yukako and HARADA, Naoki and TANOUE, Yoshihide and WATANABE, Yoshiyuki},
 issue = {5},
 journal = {Anticancer research},
 month = {May},
 note = {Background/aim: 
Few previous studies have evaluated the effectiveness of single-isocenter multitarget (SIMT) stereotactic radiosurgery (SRS) in clinical practice., Patients and methods:
Gross tumor volumes of 113 metastases in 13 patients were measured by contrast-enhanced magnetic resonance imaging. Prescribed doses were set at 20-24 Gy. Based on tumor reduction rates (TRRs) measured before and after SIMT SRS, tumor shrinkage effect was categorized into four grades; almost disappeared: TRR=1, decreased: 0.3≤TRR<1, stable: -0.2<TRR<0.3 and increased: TRR≤-0.2. Tumor shrinkage effects were compared among 3 groups; near group with a distance of <3.2 cm, middle group with a distance of ≥3.2 cm and <6.4 cm, and far group with a distance of ≥6.4 cm, categorized by distance from the isocenter., Results:
Median survival time was 17 months, with 63.7%, 11.5% and 12.4% of metastases corresponded to almost disappeared, decreased and stable, respectively. No significant difference was found in the distribution for TRRs among 3 groups., Conclusion:
Good local control of multiple brain metastases was demonstrated by SIMT SRS, irrespective of distance from the isocenter., Journal Article},
 pages = {2575--2581},
 title = {Effective Control of Brain Metastases Irrespective of Distance from Isocenter in Single-isocenter Multitarget Stereotactic Radiosurgery.},
 volume = {41},
 year = {2021}
}