@article{oai:shiga-med.repo.nii.ac.jp:00003846,
 author = {賀来, 良輔 and 余田, 誠 and 白鳥, 琢也 and 林, 一喜 and 岡本, 圭伍 and 大塩, 恭彦 and 中野, 恭幸 and 花岡, 淳 and KAKU, Ryosuke and YODEN, Makoto and SHIRATORI, Takuya and HAYASHI, Kazuki and OKAMOTO, Keigo and OHSHIO, Yasuhiko and NAKANO, Yasutaka and HANAOKA, Jun},
 issue = {3},
 journal = {Journal of Thoracic Disease},
 month = {Mar},
 note = {pdf, Background:
Respiratory function declines after lung resection. However, perioperative changes in respiratory impedance and their clinical significance are unclear. The forced oscillation technique can measure respiratory impedance during quiet breathing and possibly early after surgery. We investigated respiratory impedance changes before and after lung lobectomy and examined the correlation of impedance with clinical factors., Methods:
We prospectively included patients who underwent lobectomy between February 2018 and March 2020 and measured respiratory impedance by forced oscillation preoperatively and postoperative days 1 and 7. We statistically analyzed changes in perioperative forced oscillation measurements and their correlation with clinical factors, including subjective symptoms. The modified British Medical Research Council scale and the chronic obstructive pulmonary disease (COPD) assessment test were used for scoring subjective symptoms., Results:
Forty-four subjects were included, in whom respiratory impedance could be measured from postoperative day 1. The respective mean values for forced oscillation measurements preoperatively and at postoperative days 1 and 7 were as follows: respiratory resistance, 5 Hz: 2.28, 2.77, and 2.75; respiratory resistance, 20 Hz: 2.00, 2.36, and 2.32; difference in respiratory resistance at 5 and 20 Hz: 0.28, 0.40, and 0.43; respiratory reactance, 5 Hz: -0.31, -0.65, and -0.56; resonant frequency: 7.45, 10.41, and 9.81; and low-frequency reactance area: 1.33, 3.27, and 2.84. These changes were statistically significant (P<0.01). Besides the difference in respiratory resistance at 5 and 20 Hz, all other measurements on postoperative day 7 were relatively weakly correlated with the modified Medical Research Council scale score at this time point (all P<0.05). Respiratory complications correlated with the respiratory resistance difference, respiratory reactance, and resonant frequency on day 7 (R =0.415, -0.421, and 0.441), while the latter also correlated with postoperative hypoxemia on day 1 (R =0.433)., Conclusions:
Respiratory impedance was measurable even early after surgery and significantly changed postoperatively. As the sample size was small and appeared to be biased, assessing respiratory impedance and clinical factors in detail was difficult. Since respiratory impedance is suggested to be associated with clinical factors that affect the postoperative course, it is necessary to accumulate cases and observe them over longer periods., Journal Article},
 pages = {1347--1357},
 title = {Perioperative changes in respiratory impedance in lobectomy and their clinical impact.},
 volume = {13},
 year = {2021}
}