{"created":"2023-06-19T10:43:35.483281+00:00","id":3834,"links":{},"metadata":{"_buckets":{"deposit":"f7d44aa8-9abf-4c8b-8884-6b0bff9b1b3a"},"_deposit":{"created_by":11,"id":"3834","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"3834"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00003834","sets":["19:82:83","30:50:193","77:78:79"]},"author_link":["3728","8449","2737","7666","8452","8451","8450","675","8453","677"],"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicVolumeNumber":"10","bibliographic_titles":[{},{"bibliographic_title":"Translational Vision Science and Technology","bibliographic_titleLang":"en"}]}]},"item_4_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"今村, 拓"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"柿木, 雅志"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"平, 大樹"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"寺田, 智祐"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"河本, 育士"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"村瀬, 充"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"大路, 正人"}],"nameIdentifiers":[{},{}]}]},"item_4_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"pdf","subitem_description_type":"Other"}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose:\nThis study evaluated the pharmacokinetics of intravitreal vancomycin and ceftazidime in the aqueous humor of macaque eyes filled with silicone oil in the vitreous cavity.","subitem_description_type":"Abstract"},{"subitem_description":"Methods:\nIntravitreal vancomycin (1 mg/0.1 mL) and ceftazidime (2 mg/0.1 mL) were injected into four normal macaque eyes, four vitrectomized aphakic macaque eyes, and four previously vitrectomized aphakic macaque eyes filled with silicone oil (silicone oil-filled eyes). Aqueous humor samples (0.1 mL) were obtained just before injection and at 2 and 5 hours and 1, 2, 3, 5, 7, and 10 days after injection. In each group, corneal endothelial cell density (ECD) measurements and electroretinogram (ERG) recordings were obtained before injection and after 1 month.","subitem_description_type":"Abstract"},{"subitem_description":"Results:\nThe half-lives of vancomycin in the aqueous humor of normal, vitrectomized, and silicone oil-filled eyes were 29.4, 21.1, and 6.8 hours, respectively, and those of ceftazidime were 20.4, 5.2, and 3.1 hours, respectively. The maximum vancomycin aqueous humor concentrations of normal, vitrectomized, and silicone oil-filled eyes were 151.4, 205.6, and 543.5 µg/mL, respectively, and the maximum ceftazidime aqueous humor concentrations are 64.6, 260.0, and 1176.3 µg/mL, respectively. There was no change in ECD, and ERG was not declined after intravitreal injection in all groups.","subitem_description_type":"Abstract"},{"subitem_description":"Conclusions:\nThe half-lives of vancomycin and ceftazidime in the aqueous humor were shorter in silicone oil-filled eyes than in normal and vitrectomized eyes. High antibiotic concentrations in silicone oil-filled eyes seemed to be well tolerated.","subitem_description_type":"Abstract"},{"subitem_description":"Translational Relevance:\nThis study aids in estimating how often an antibiotic should be intravitreally injected for endophthalmitis of silicone oil-filled eyes.","subitem_description_type":"Abstract"}]},"item_4_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article","subitem_description_type":"Other"}]},"item_4_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Association for Research in Vision and Ophthalmology Inc."}]},"item_4_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1167/tvst.10.3.1"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1167/tvst.10.3.1","subitem_relation_type_select":"DOI"}}]},"item_4_relation_13":{"attribute_name":"PMCID","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"PMC7938004"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7938004/","subitem_relation_type_select":"URI"}}]},"item_4_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright 2021 The Authors"}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"21642591","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"IMAMURA, Taku"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KAKINOKI, Masashi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"HIRA, Daiki"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"KITAGAWA, Tomoya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"UESHIMA, Satoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KAKUMOTO, Mikio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TERADA, Tomohiro"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"KAWAMOTO, Ikuo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MURASE, Mitsuru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"OHJI, Masahito"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-04-12"}],"displaytype":"detail","filename":"tvst.10.3.1.pdf","filesize":[{"value":"590.5 kB"}],"format":"application/pdf","license_note":"This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"tvst.10.3.1","url":"https://shiga-med.repo.nii.ac.jp/record/3834/files/tvst.10.3.1.pdf"},"version_id":"5003d8a5-342e-420d-b975-6f3d6dcc4916"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"vancomycin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ceftazidime","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"silicone oil","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"macaque","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Pharmacokinetics of Intravitreal Vancomycin and Ceftazidime in Silicone Oil-Filled Macaque Eyes.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Pharmacokinetics of Intravitreal Vancomycin and Ceftazidime in Silicone Oil-Filled Macaque Eyes."}]},"item_type_id":"4","owner":"11","path":["79","83","193"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-04-12"},"publish_date":"2021-04-12","publish_status":"0","recid":"3834","relation_version_is_last":true,"title":["Pharmacokinetics of Intravitreal Vancomycin and Ceftazidime in Silicone Oil-Filled Macaque Eyes."],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-06-19T11:37:09.211598+00:00"}