{"created":"2023-06-19T10:43:35.227333+00:00","id":3828,"links":{},"metadata":{"_buckets":{"deposit":"2f8ac50a-775d-4996-9e14-b8d5da889d7f"},"_deposit":{"created_by":11,"id":"3828","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"3828"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00003828","sets":["30:227:228","77:319:320"]},"author_link":["1869","706","7638","644","7565","7639","538","7509"],"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"163","bibliographicPageStart":"156","bibliographicVolumeNumber":"68","bibliographic_titles":[{},{"bibliographic_title":"Journal of Clinical Biochemistry and Nutrition","bibliographic_titleLang":"en"}]}]},"item_4_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"西野, 恭平"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"西田, 淳史"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"稲富, 理"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"今井, 隆行"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"久米, 真司"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"河原, 真大"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"前川, 聡"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"安藤, 朗"}],"nameIdentifiers":[{},{},{}]}]},"item_4_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"pdf","subitem_description_type":"Other"}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Autophagy-associated genes have been identified as susceptible loci for inflammatory bowel disease. We investigated the role of a core autophagy factor, Atg5, in the development of dextran sodium sulfate (DSS)-induced colitis. Intestinal epithelial cell (IEC)-specific Atg5 gene deficient mice (Atg5ΔIEC mice) were generated by cross of Atg5-floxed mice (Atg5fl/fl) with transgenic mice expressing Cre-recombinase driven by the villin promotor. Mice were given three cycles of 1.5% DSS in drinking water for 5 days and regular water for 14 days over a 60-day period. The dysfunction of autophagy characterized by a marked accumulation of p62 protein, a substrate for autophagy degradation, was detected in epithelial cells in the non-inflamed and inflamed mucosa of inflammatory bowel disease patients. DSS-colitis was exacerbated in Atg5ΔIEC mice compared to control Atg5fl/fl mice. Phosphorylation of inositol-requiring transmembrane kinase/endonuclease1α (IRE1α), a sensor for endoplasmic reticulum stress, and c-Jun N-terminal kinase, a downstream target of IRE1α, were significantly enhanced in IECs in DSS-treated Atg5ΔIEC mice. Accumulation of phosphorylated IRE1α was enhanced by the treatment with chloroquine, an autophagy inhibitor. Apoptotic IECs were more abundant in DSS-treated Atg5ΔIEC mice. These findings suggest that Atg5 suppresses endoplasmic reticulum stress-induced apoptosis of IECs via the degradation of excess p-IRE1α.","subitem_description_type":"Abstract"}]},"item_4_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article","subitem_description_type":"Other"}]},"item_4_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"一般社団法人　日本酸化ストレス学会"}]},"item_4_publisher_34":{"attribute_name":"別言語の出版者","attribute_value_mlt":[{"subitem_publisher":"SOCIETY FOR FREE RADICAL RESEARCH JAPAN"}]},"item_4_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.3164/jcbn.20-90"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3164/jcbn.20-90","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"130007993417","subitem_relation_type_select":"NAID"}}]},"item_4_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2021 JCBN"}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0912-0009","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"NISHINO, Kyohei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NISHIDA, Atsushi"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"INATOMI, Osamu"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"IMAI, Takayuki"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"KUME, Shinji"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"KAWAHARA, Masahiro"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"MAEGAWA, Hiroshi"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"ANDOH, Akira"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-04-07"}],"displaytype":"detail","filename":"jcbn.20-90.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","license_note":"This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License.\nhttps://creativecommons.org/licenses/by-nc-nd/4.0/","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"jcbn.20-90","url":"https://shiga-med.repo.nii.ac.jp/record/3828/files/jcbn.20-90.pdf"},"version_id":"a5d27f73-23dc-48d0-8ebc-9f51a464beaa"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"autophagy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"IRE1α","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"IBD","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Targeted deletion of Atg5 in intestinal epithelial cells promotes dextran sodium sulfate-induced colitis.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Targeted deletion of Atg5 in intestinal epithelial cells promotes dextran sodium sulfate-induced colitis."}]},"item_type_id":"4","owner":"11","path":["228","320"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-04-07"},"publish_date":"2021-04-07","publish_status":"0","recid":"3828","relation_version_is_last":true,"title":["Targeted deletion of Atg5 in intestinal epithelial cells promotes dextran sodium sulfate-induced colitis."],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-06-19T11:37:15.622051+00:00"}