@article{oai:shiga-med.repo.nii.ac.jp:00003791,
 author = {椎野, 顯彦 and 藤吉, 朗 and 門田, 文 and 近藤, 慶子 and 伊藤, 隆洋 and 瀬川, 裕佳 and 和氣, 宗 and 宮川, 尚子 and 遠山, 育夫 and 上島, 弘嗣 and 三浦, 克之 and SYAIFULLAH, Ali Haidar and SHIINO, Akihiko and FUJIYOSHI, Akira and KADOTA, Aya and KONDO, Keiko and ITO, Takahiro and SEGAWA, Hiroyoshi and MONIRUZZAMAN, Mohammad and WAKI, Takashi and MIYAGAWA, Naoko and TOOYAMA, Ikuo and UESHIMA, Hirotsugu and MIURA, Katsuyuki},
 journal = {Alcohol (Fayetteville, N.Y.)},
 month = {Dec},
 note = {The clinical implications of alcohol consumption have been extensively examined; however, its effects on brain structures in apparently healthy community-dwellers remain unclear. Therefore, we investigated the relationship between alcohol consumption and brain gray matter volume (GMV) in community-dwelling Japanese men using voxel-based morphometry (VBM). We recruited cognitively intact Japanese men, aged 40-79 years, from a population-based cohort in Shiga, Japan. Brain magnetic resonance imaging was performed, on average, 2 years after demographic and medical information was obtained in 2010-2014. A multivariable linear regression analysis of 639 men was conducted to elucidate the relationship between the amount of alcohol consumed and GMV. VBM statistics were analyzed by threshold-free cluster enhancement with a family-wise error rate of <0.05. The results obtained demonstrated that the amount of alcohol consumed was associated with lower GMV. The VBM analysis showed lower GMV within the parahippocampal, entorhinal, cingulate, insular, temporal, and frontal cortices and cerebellum in very heavy drinkers (≥42 ethanol g/day) than in non-drinkers. Furthermore, alcohol consumption was associated with a higher white matter lesion volume. These results suggest subclinical structural changes similar to alcohol-related neurological diseases., Journal Article, Research members：
Minoru Horie, Yoshihisa Nakagawa, Takashi Yamamoto, Yasutaka Nakano, Emiko Ogawa, Hiroshi Maegawa, Katsutaro Morino, Itsuko Miyazawa, Yoshiyuki Watanabe, Kazuhiko Nozaki, Ikuo Tooyama, Akihiko Shiino, Akira Andoh, Teruhiko Tsuru, Hisakazu Ogita, Naomi Miyamatsu, Yasuyuki Nakamura, Aya Kadota, Keiko Kondo, Sayuki Torii, Takashi Kadowaki, Sayaka Kadowaki, Sentaro Suzuki, Takahiro Ito, Ayako Kunimura, Hiroyoshi Segawa, Akira Fujiyoshi, Aya Higashiyama, Tomonori Okamura, Koichiro Azuma, Tatsuya Sawamura, Michiya Igase, Yasuharu Tabara, Akira Sekikawa, Emma J M Barinas-Mitchell, Daniel Edmundowicz, Takayoshi Ohkubo, Atsushi Hozawa, Yoshitaka Murakam, Nagako Okuda, Hisatomi Arima, Atsushi Satoh, Yoshikuni Kita, Takashi Hisamatsu, Masahiko Yanagita, Robert D Abbott, Seiko Ohno, Naoyuki Takashima, Naoko Miyagawa, Maryam Zaid, Yoshino Saito},
 pages = {57--65},
 title = {Alcohol drinking and brain morphometry in apparently healthy community-dwelling Japanese men.},
 volume = {90},
 year = {2020}
}