{"created":"2023-06-19T10:43:33.135746+00:00","id":3787,"links":{},"metadata":{"_buckets":{"deposit":"094ba586-d4ce-4f83-a5f5-77a11fbf5ab9"},"_deposit":{"created_by":11,"id":"3787","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"3787"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00003787","sets":["30:191:192","30:234:235"]},"author_link":["3737","795","701","1961","3220","1857","8339","7903"],"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-02","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"105","bibliographicPageStart":"97","bibliographicVolumeNumber":"554","bibliographic_titles":[{},{"bibliographic_title":"Virology","bibliographic_titleLang":"en"}]}]},"item_4_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"石垣, 宏仁"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"仲山, 美沙子"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"北川, 善紀"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"林, 香里"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"塩原, 正規"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"後藤, 敏"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"伊藤, 靖"}],"nameIdentifiers":[{},{}]}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We examined the pathogenicity of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in cynomolgus macaques for 28 days to establish an animal model of COVID-19 for the development of vaccines and antiviral drugs. Cynomolgus macaques infected with SARS-CoV-2 showed body temperature rises and X-ray radiographic pneumonia without life-threatening clinical signs of disease. A neutralizing antibody against SARS-CoV-2 and T-lymphocytes producing interferon (IFN)-γ specifically for SARS-CoV-2 N-protein were detected on day 14 in one of three macaques with viral pneumonia. In the other two macaques, in which a neutralizing antibody was not detected, T-lymphocytes producing IFN-γ specifically for SARS-CoV-2 N protein increased on day 7 to day 14, suggesting that not only a neutralizing antibody but also cellular immunity has a role in the elimination of SARS-CoV-2. Thus, because of similar symptoms to approximately 80% of patients, cynomolgus macaques are appropriate to extrapolate the efficacy of vaccines and antiviral drugs for humans.","subitem_description_type":"Abstract"}]},"item_4_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article","subitem_description_type":"Other"}]},"item_4_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_4_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"33412411","subitem_relation_type_select":"PMID"}}]},"item_4_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1016/j.virol.2020.12.013"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.virol.2020.12.013","subitem_relation_type_select":"DOI"}}]},"item_4_relation_13":{"attribute_name":"PMCID","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"PMC7771262"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7771262/","subitem_relation_type_select":"URI"}}]},"item_4_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2020. Published by Elsevier Inc. "}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1096-0341","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ISHIGAKI, Hirohito"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"NAKAYAMA, Misako"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"KITAGAWA, Yoshinori"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"NGUYEN, Cong Thanh"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"HAYASHI, Kaori"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"SHIOHARA, Masanori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"GOTOH, Bin"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"ITOH, Yasushi"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-01-22"}],"displaytype":"detail","filename":"j.virol.2020.12.013.pdf","filesize":[{"value":"4.9 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"j.virol.2020.12.013","url":"https://shiga-med.repo.nii.ac.jp/record/3787/files/j.virol.2020.12.013.pdf"},"version_id":"86e864f4-447a-4d66-83aa-c48b016fbe15"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Neutralizing antibody","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Nonhuman primate","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Pneumonia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"SARS-CoV-2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Th1 response","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Thrombus","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Neutralizing antibody-dependent and -independent immune responses against SARS-CoV-2 in cynomolgus macaques.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Neutralizing antibody-dependent and -independent immune responses against SARS-CoV-2 in cynomolgus macaques."}]},"item_type_id":"4","owner":"11","path":["192","235"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-01-22"},"publish_date":"2021-01-22","publish_status":"0","recid":"3787","relation_version_is_last":true,"title":["Neutralizing antibody-dependent and -independent immune responses against SARS-CoV-2 in cynomolgus macaques."],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-06-19T11:39:19.495272+00:00"}