@article{oai:shiga-med.repo.nii.ac.jp:00003787,
 author = {石垣, 宏仁 and 仲山, 美沙子 and 北川, 善紀 and 林, 香里 and 塩原, 正規 and 後藤, 敏 and 伊藤, 靖 and ISHIGAKI, Hirohito and NAKAYAMA, Misako and KITAGAWA, Yoshinori and NGUYEN, Cong Thanh and HAYASHI, Kaori and SHIOHARA, Masanori and GOTOH, Bin and ITOH, Yasushi},
 journal = {Virology},
 month = {Feb},
 note = {We examined the pathogenicity of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in cynomolgus macaques for 28 days to establish an animal model of COVID-19 for the development of vaccines and antiviral drugs. Cynomolgus macaques infected with SARS-CoV-2 showed body temperature rises and X-ray radiographic pneumonia without life-threatening clinical signs of disease. A neutralizing antibody against SARS-CoV-2 and T-lymphocytes producing interferon (IFN)-γ specifically for SARS-CoV-2 N-protein were detected on day 14 in one of three macaques with viral pneumonia. In the other two macaques, in which a neutralizing antibody was not detected, T-lymphocytes producing IFN-γ specifically for SARS-CoV-2 N protein increased on day 7 to day 14, suggesting that not only a neutralizing antibody but also cellular immunity has a role in the elimination of SARS-CoV-2. Thus, because of similar symptoms to approximately 80% of patients, cynomolgus macaques are appropriate to extrapolate the efficacy of vaccines and antiviral drugs for humans., Journal Article},
 pages = {97--105},
 title = {Neutralizing antibody-dependent and -independent immune responses against SARS-CoV-2 in cynomolgus macaques.},
 volume = {554},
 year = {2021}
}