@article{oai:shiga-med.repo.nii.ac.jp:00003768,
 author = {三宅, 亨 and 飯田, 洋也 and 清水, 智治 and 植木, 智之 and 小島, 正継 and 太田, 裕之 and 山口, 剛 and 貝田, 佐知子 and 目片, 英治 and 遠藤, 善裕 and 谷, 眞至 and MIYAKE, Toru and IIDA, Hiroya and SHIMIZU, Tomoharu and UEKI, Tomoyuki and KOJIMA, Masatsugu and OHTA, Hiroyuki and YAMAGUCHI, Tsuyoshi and KAIDA, Sachiko and MEKATA, Eiji and ENDO, Yoshihiro and TANI, Masaji},
 journal = {Digestive surgery},
 month = {Nov},
 note = {Background:
Procalcitonin (PCT) is a well-known marker for bacterial infection; however, the clinical significance of PCT in the long-term prognosis after colorectal cancer (CRC) surgery remains unclear., Methods:
This is a retrospective review of 277 patients that underwent CRC surgery to investigate the relationship between preoperative PCT, clinicopathological condition, cancer-specific overall survival (OS), and relapse-free survival (RFS)., Results:
Median follow-up interval was 5.0 years in all patients. Thirty-six patients developed recurrence, and 46 patients died due to recurrences or metastases of CRC. Preoperative PCT levels were highest in Stage IV patients. The cancer-specific OS in patients with Stage IV/PCT ≤0.05 ng/mL was significantly higher than those with Stage IV/PCT >0.05 ng/mL (3 years survival; 42.3 vs. 14.3%, p = 0.0413). On multivariate analysis, gender, TNM classification, and PCT were identified as significant risk factors for cancer-specific OS in patients with Stage I-III CRC. The cancer-specific OS rate of these patients with PCT ≥0.08 ng/mL, compared with PCT <0.08 ng/mL, was significantly decreased (5 years survival; 59.1 vs. 92.7%, p < 0.0001). TNM classification was finally identified as an independent risk factor for cancer-specific RFS in these patients by multivariate analysis., Conclusion:
High preoperative PCT values in CRC patients appeared to be associated with poor OS but not RFS following surgical treatments., Journal Article},
 pages = {1--7},
 title = {The Elevation in Preoperative Procalcitonin Is Associated with a Poor Prognosis for Patients Undergoing Resection for Colorectal Cancer.},
 year = {2020}
}