{"created":"2023-06-19T10:43:29.444061+00:00","id":3718,"links":{},"metadata":{"_buckets":{"deposit":"a1f90b53-1438-4b1a-8c10-64e4ad2e9a23"},"_deposit":{"created_by":11,"id":"3718","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"3718"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00003718","sets":["30:204:205","30:236:237"]},"author_link":["193","696","268","339","194","702"],"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-10-19","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{},{"bibliographic_title":"Surgery","bibliographic_titleLang":"en"}]}]},"item_4_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"赤堀, 浩也"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"山本, 寛"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"清水, 智治"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"遠藤, 善裕"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"谷, 徹"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"谷, 眞至"}],"nameIdentifiers":[{},{},{}]}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background:\nMechanisms underlying hemodynamic disturbance in hemorrhagic shock are not completely understood. Transient receptor potential vanilloid 1-expressing afferents are involved in hemorrhagic shock pathology, and transient receptor potential vanilloid 1 antagonist, capsazepine, acts on the central nervous system to improve mortality in a rat hemorrhagic shock model. In contrast, transient receptor potential vanilloid 1-positive efferents promote vasoactive reactions through the release of neuropeptides, including calcitonin gene-related peptides. This study aimed to investigate whether transient receptor potential vanilloid 1-positive peripheral sensory efferents are involved in hemodynamic responses after hemorrhagic shock. ","subitem_description_type":"Abstract"},{"subitem_description":"Methods:\nMale rats underwent hemorrhagic shock (mean arterial pressure 30 mm Hg for 90 min, followed by resuscitation for 30 min) and received capsazepine (5 μM/kg) 30 min after shock induction. A separate cohort of rats subjected to hemorrhagic shock received hCGRP8-37 (300 μg/kg), a calcitonin gene-related peptide receptor antagonist, at 30, 60, or 90 minutes after shock induction. The 24-hour survival rate, mean arterial pressure, heart rate, arterial blood gas, and plasma calcitonin gene-related peptide levels were measured. Tissue blood flow and oxygenation both in the mesentery and skeletal muscle were also assessed. ","subitem_description_type":"Abstract"},{"subitem_description":"Results:\nCapsazepine treatment prevented the hemorrhagic shock-induced increase in plasma calcitonin gene-related peptide levels, and hCGRP8-37 treatment improved the 24-h survival rates after hemorrhagic shock at a time-dependent manner. The hCGRP8-37- or capsazepine-treated rats exhibited tissue oxygenation and metabolic conditions comparable to those in control rats at the end of the experiment. ","subitem_description_type":"Abstract"},{"subitem_description":"Conclusion:\nTransient receptor potential vanilloid 1 plays a crucial role in hemodynamic responses to hemorrhagic shock, partly via calcitonin gene-related peptide release, involved in its peripheral sensory-efferent functions. The hCGRP8-37 appears to improve peripheral circulatory failure, which may be useful as adjunct treatment after hemorrhagic shock. ","subitem_description_type":"Abstract"}]},"item_4_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article","subitem_description_type":"Other"}]},"item_4_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Mosby Inc."}]},"item_4_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"33092809","subitem_relation_type_select":"PMID"}}]},"item_4_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1016/j.surg.2020.09.007"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.surg.2020.09.007","subitem_relation_type_select":"DOI"}}]},"item_4_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2020 Elsevier Inc. All rights reserved."}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1532-7361","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"AKABORI, Hiroya"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"YAMAMOTO, Hiroshi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"SHIMIZU, Tomoharu"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"ENDO, Yoshihiro"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"TANI, Tohru"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"TANI, Masaji"}],"nameIdentifiers":[{},{},{}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Involvement of TRPV1-containing peripheral sensory efferents in hemodynamic responses in a rat hemorrhagic shock model.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Involvement of TRPV1-containing peripheral sensory efferents in hemodynamic responses in a rat hemorrhagic shock model."}]},"item_type_id":"4","owner":"11","path":["205","237"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-11-02"},"publish_date":"2020-11-02","publish_status":"0","recid":"3718","relation_version_is_last":true,"title":["Involvement of TRPV1-containing peripheral sensory efferents in hemodynamic responses in a rat hemorrhagic shock model."],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-06-19T11:56:07.527270+00:00"}