{"created":"2023-06-19T10:43:29.399944+00:00","id":3717,"links":{},"metadata":{"_buckets":{"deposit":"7b9254f5-cb73-43d2-bd85-afdc7a720407"},"_deposit":{"created_by":11,"id":"3717","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"3717"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00003717","sets":["19:82:83"]},"author_link":["8232","8237","8236","8233","8238","8235","8234","6470"],"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-09-29","bibliographicIssueDateType":"Issued"},"bibliographicVolumeNumber":"12","bibliographic_titles":[{},{"bibliographic_title":"Frontiers in Aging Neuroscience","bibliographic_titleLang":"en"}]}]},"item_4_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"渡部, 千里"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"依馬, 正次"}],"nameIdentifiers":[{},{},{}]}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Vertebrates have acquired complex high-order functions facilitated by the dispersion of vascular and neural networks to every corner of the body. Blood vessels deliver oxygen and nutrients to all cells and provide essential transport systems for removing waste products. For these functions, tissue vascularization must be spatiotemporally appropriate. Recent studies revealed that blood vessels create a tissue-specific niche, thus attracting attention as biologically active sites for tissue development. Each capillary network is critical for maintaining proper brain function because age-related and disease-related impairment of cognitive function is associated with the loss or diminishment of brain capillaries. This review article highlights how structural and functional alterations in the brain vessels may change with age and neurogenerative diseases. Capillaries are also responsible for filtering toxic byproducts, providing an appropriate vascular environment for neuronal function. Accumulation of amyloid β is a key event in Alzheimer’s disease pathogenesis. Recent studies have focused on associations reported between Alzheimer’s disease and vascular aging. Furthermore, the glymphatic system and meningeal lymphatic systems contribute to a functional unit for clearance of amyloid β from the brain from the central nervous system into the cervical lymph nodes. This review article will also focus on recent advances in stem cell therapies that aim at repopulation or regeneration of a degenerating vascular system for neural diseases.","subitem_description_type":"Abstract"}]},"item_4_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article","subitem_description_type":"Other"}]},"item_4_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Frontiers Media S.A."}]},"item_4_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.3389/fnagi.2020.557384"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3389/fnagi.2020.557384","subitem_relation_type_select":"DOI"}}]},"item_4_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2020 Watanabe, Imaizumi, Kawai, Suda, Honma, Ichihashi, Ema and Mizutani. "}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"16634365","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"WATANABE, Chisato"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"IMAIZUMI, Tsutomu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"KAWAI, Hiromi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SUDA, Kazuma"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HONMA, Yoichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"ICHIHASHI, Masamitsu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"EMA, Masatsugu"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"MIZUTANI, Ken-Ichi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-30"}],"displaytype":"detail","filename":"fnagi.2020.557384.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","license_note":"This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"fnagi.2020.557384","url":"https://shiga-med.repo.nii.ac.jp/record/3717/files/fnagi.2020.557384.pdf"},"version_id":"92e8f040-d019-4df9-8147-6889be9ff3df"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"vascular system","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"capillary vessels","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"neocortex","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"vascular aging","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"neural diseases","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Aging of the Vascular System and Neural Diseases.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Aging of the Vascular System and Neural Diseases."}]},"item_type_id":"4","owner":"11","path":["83"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-10-30"},"publish_date":"2020-10-30","publish_status":"0","recid":"3717","relation_version_is_last":true,"title":["Aging of the Vascular System and Neural Diseases."],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-06-19T11:56:08.490979+00:00"}