@article{oai:shiga-med.repo.nii.ac.jp:00003649,
 author = {林, 香里 and 仲山, 美沙子 and 岩谷, 千鶴 and 土屋, 英明 and 中村, 紳一郎 and 伊藤, 靖 and 辻, 俊一郎 and 石垣, 宏仁 and 村上, 節 and 小笠原, 一誠 and HAYASHI, Kaori and NAKAYAMA, Misako and IWATANI, Chizuru and TSUCHIYA, Hideaki and NAKAMURA, Shinichiro and NONOGUCHI, Kosuke and ITOH, Yasushi and TSUJI, Shunichiro and ISHIGAKI, Hirohito and MORI, Takahide and MURAKAMI, Takashi and OGASAWARA, Kazumasa},
 issue = {4},
 journal = {The Tohoku journal of experimental medicine},
 month = {},
 note = {Endometriosis, a disease in which endometrial tissue proliferates outside the uterus, is a progressive disease that affects women in reproductive age. It causes abdominal pain and infertility that severely affects the quality of life in young women. The mechanism of the onset and development of endometriosis has not been fully elucidated because of the complex mechanism involved in the disease. Nonhuman primates have been used to study the pathogenesis of spontaneous endometriosis because of their gynecological and anatomical similarities to humans. To reveal the natural history of endometriosis in cynomolgus monkeys, we selected 11 female cynomolgus monkeys with spontaneous endometriosis and performed monthly laparoscopies, mapping endometriotic lesions and adhesions up to two years. At the initial laparoscopy, endometriotic lesions were exclusively found in the vesicouterine pouch in 45.4% (5/11) of the monkeys and spread to the Douglas' pouch over time. Appearance of small de novo lesions and disappearance of some of the small lesions were observed in 100% (11/11) and 18.2% (2/11) of the monkeys, respectively. Endometriosis developed in all monkeys, and the speed of progression varied greatly among individuals that could be attributed to the degree or frequency of retrograde menstruation and genetic factors; these findings support the similarities between humans and monkeys, thus verifying the value of this nonhuman primate model. Finding reliable quantification markers and unravelling the underlying factors in correlation with the spatiotemporal development of the disease using a nonhuman primate model would be useful for the better management of endometriosis in humans., Journal Article},
 pages = {241--253},
 title = {The Natural History of Spontaneously Occurred Endometriosis in Cynomolgus Monkeys by Monthly Follow-Up Laparoscopy for Two Years.},
 volume = {251},
 year = {2020}
}