{"created":"2023-06-19T10:43:25.338930+00:00","id":3647,"links":{},"metadata":{"_buckets":{"deposit":"52a776cc-a085-40d1-90f5-24e83d2c39f2"},"_deposit":{"created_by":11,"id":"3647","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"3647"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00003647","sets":["30:42:318"]},"author_link":["8052","8053","8049","7308","8050","6422","8054","8051"],"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-07-19","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{},{"bibliographic_title":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","bibliographic_titleLang":"en"}]}]},"item_4_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"大野, 美紀子"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"岩崎, 広高"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"西, 英一郎"}],"nameIdentifiers":[{},{}]}]},"item_4_description_31":{"attribute_name":"目次","attribute_value_mlt":[{"subitem_description":" .","subitem_description_type":"Other"}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Cardiac sympathetic innervation is critically involved in the regulation of circulatory dynamics. However, the molecular mechanism for the innervation patterning has remained elusive. Here, we demonstrate that nardilysin (NRDC, Nrdc), an enhancer of ectodomain shedding, regulates cardiac sympathetic innervation. Nardilysin-deficient (Nrdc-/- ) mice show hypoplastic hearts, hypotension, bradycardia, and abnormal sympathetic innervation patterning. While the innervation of left ventricle (LV) of wild-type mice is denser in the subepicardium than in the subendocardium, Nrdc-/- LV lacks such a polarity and is uniformly and more abundantly innervated. At the molecular level, the full-length form of p75 neurotrophin receptor (p75NTR , Ngfr) is increased in Nrdc-/- LV due to the reduced ectodomain shedding of p75NTR . Importantly, the reduction of p75NTR rescued the abnormal innervation phenotype of Nrdc-/- mice. Moreover, sympathetic neuron-specific, but not cardiomyocyte-specific deletion of Nrdc recapitulated the abnormal innervation patterning of Nrdc-/- mice. In conclusion, neuronal nardilysin critically regulates cardiac sympathetic innervation and circulatory dynamics via modulation of p75NTR . ","subitem_description_type":"Abstract"}]},"item_4_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article","subitem_description_type":"Other"}]},"item_4_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Wiley"}]},"item_4_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"32683751","subitem_relation_type_select":"PMID"}}]},"item_4_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1096/fj.202000604R"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1096/fj.202000604r","subitem_relation_type_select":"DOI"}}]},"item_4_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2020 Federation of American Societies for Experimental Biology."}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1530-6860","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"OHNO, Mikiko"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"NISHI, Kiyoto"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"HIRAOKA, Yoshinori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NIIZUMA, Shinichiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MATSUDA, Shintaro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"IWASAKI, Hirotaka"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"KIMURA, Takeshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NISHI, Eiichiro"}],"nameIdentifiers":[{},{}]}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Heart","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ectodomain shedding","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"nardilysin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"p75NTR","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"sympathetic nerve","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Nardilysin controls cardiac sympathetic innervation patterning through regulation of p75 neurotrophin receptor.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Nardilysin controls cardiac sympathetic innervation patterning through regulation of p75 neurotrophin receptor."}]},"item_type_id":"4","owner":"11","path":["318"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-07-27"},"publish_date":"2020-07-27","publish_status":"0","recid":"3647","relation_version_is_last":true,"title":["Nardilysin controls cardiac sympathetic innervation patterning through regulation of p75 neurotrophin receptor."],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-06-19T12:11:28.554969+00:00"}