@article{oai:shiga-med.repo.nii.ac.jp:00003609,
 author = {高嶋, 直敬 and 有馬, 久富 and 喜多, 義邦 and 藤居, 貴子 and 田中, 佐智子 and 設楽, 智史 and 北村, 彰浩 and 三浦, 克之 and 野﨑, 和彦 and TAKASHIMA, Naoyuki and ARIMA, Hisatomi and KITA, Yoshikuni and FUJII, Takako and Tanaka-Mizuno, Sachiko and SHITARA, Satoshi and KITAMURA, Akihiro and MIURA, Katsuyuki and NOZAKI, Kazuhiko and Shiga Stroke and Heart Attack Registry Group},
 issue = {6},
 journal = {Circulation journal : official journal of the Japanese Circulation Society},
 month = {May},
 note = {Background:
Despite many effective strategies for the prevention of recurrent stroke, individuals who survive an initial stroke have been shown to be at high risk of recurrent stroke. The aim of this study was to investigate the current status of stroke recurrence after first-ever stroke using a population-based stroke registry in Japan.Methods and Results:As part of the Shiga Stroke and Heart Attack Registry, the Shiga Stroke Registry is an ongoing population-based stroke registry study that covers approximately 1.4 million residents of Shiga Prefecture, Japan. A total of 1,883 first-ever stroke survivors at 28 days was registered in 2011 and followed-up until the end of 2013. Recurrence was defined as any type of stroke after 28 days from the onset of an index event. Two-year cumulative recurrence rates were estimated using cumulative incidence function methods. Over a mean 2.1-year follow-up period, 120 patients experienced recurrent stroke and 389 patients died without recurrence. The 2-year cumulative recurrence rate was higher in patients with index ischemic stroke (6.8%) than in those with index hemorrhagic stroke (3.8%)., Conclusions:
Two-year cumulative recurrence rate after first-ever stroke remained high, particularly among patients with ischemic stroke, in the present population-based registry study in a real-world setting in Japan. Further intensive secondary prevention strategies are required for these high-risk individuals., Journal Article},
 pages = {943--948},
 title = {Two-Year Recurrence After First-Ever Stroke in a General Population of 1.4 Million Japanese Patients - The Shiga Stroke and Heart Attack Registry Study.},
 volume = {84},
 year = {2020}
}