{"created":"2023-06-19T10:43:22.660183+00:00","id":3605,"links":{},"metadata":{"_buckets":{"deposit":"2aaaf124-e394-4d28-b15f-3de477ee40af"},"_deposit":{"created_by":11,"id":"3605","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"3605"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00003605","sets":["30:191:192","30:273:274","30:40:268"]},"author_link":["3912","1961","7872","7977","1857","1971","7832","7840"],"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-05-21","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"8414","bibliographicVolumeNumber":"10","bibliographic_titles":[{},{"bibliographic_title":"Scientific Reports","bibliographic_titleLang":"en"}]}]},"item_4_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"里岡, 大樹"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"石垣, 宏仁"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"藤堂, 景史"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"寺田, 晃士"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"縣, 保年"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"伊藤, 靖"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"小笠原, 一誠"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"平田, 多佳子"}],"nameIdentifiers":[{},{},{}]}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Immunotherapy has emerged as a promising and effective treatment for cancer, yet the clinical benefit is still variable, in part due to insufficient accumulation of immune effector cells in the tumour microenvironment. Better understanding of tumour-infiltrating lymphocytes (TILs) from nonhuman primate tumours could provide insights into improving effector cell accumulation in tumour tissues during immunotherapy. Here, we characterize TILs in a cynomolgus macaque tumour model in which the tumours were infiltrated with CD4+ and CD8+ T cells and were eventually rejected. The majority of CD4+ and CD8+ TILs exhibited a CD45RA-CCR7- effector memory phenotype, but unlike circulating T cells, they expressed CD69, a marker for tissue-resident memory T (TRM) cells. CD69-expressing CD8+ TILs expressed high levels of the cytotoxic molecule granzyme B and the co-inhibitory receptor PD-1. Consistent with the TRM cell phenotype, CD8+ TILs minimally expressed CX3CR1 but expressed CXCR3 at higher levels than circulating CD8+ T cells. Meanwhile, CXCL9, CXCL10 and CXCL11, chemokine ligands for CXCR3, were expressed at high levels in the tumours, thus attracting CXCR3+CD8+ T cells. These results indicate that tumour-transplanted macaques can be a useful preclinical model for studying and optimizing T cell accumulation in tumours for the development of new immunotherapies. ","subitem_description_type":"Abstract"}]},"item_4_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article","subitem_description_type":"Other"}]},"item_4_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature"}]},"item_4_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"32439888","subitem_relation_type_select":"PMID"}}]},"item_4_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1038/s41598-020-65488-x"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1038/s41598-020-65488-x","subitem_relation_type_select":"DOI"}}]},"item_4_relation_13":{"attribute_name":"PMCID","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"PMC7242367"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7242367/","subitem_relation_type_select":"URI"}}]},"item_4_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© The Author(s) 2020"}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2045-2322","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"SATOOKA, Hiroki"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"ISHIGAKI, Hirohito"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"TODO, Kagefumi"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"TERADA, Koji"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"AGATA, Yasutoshi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"ITOH, Yasushi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"OGASAWARA, Kazumasa"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"HIRATA, Takako"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-19"}],"displaytype":"detail","filename":"s41598-020-65488-x.pdf","filesize":[{"value":"2.5 MB"}],"format":"application/pdf","license_note":"This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"s41598-020-65488-x","url":"https://shiga-med.repo.nii.ac.jp/record/3605/files/s41598-020-65488-x.pdf"},"version_id":"7749ae8b-2ac1-40c0-ad5b-73553ebdfcef"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Characterization of tumour-infiltrating lymphocytes in a tumour rejection cynomolgus macaque model.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Characterization of tumour-infiltrating lymphocytes in a tumour rejection cynomolgus macaque model."}]},"item_type_id":"4","owner":"11","path":["192","268","274"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-06-19"},"publish_date":"2020-06-19","publish_status":"0","recid":"3605","relation_version_is_last":true,"title":["Characterization of tumour-infiltrating lymphocytes in a tumour rejection cynomolgus macaque model."],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-06-19T12:18:21.936660+00:00"}