{"created":"2023-06-19T10:43:22.595947+00:00","id":3604,"links":{},"metadata":{"_buckets":{"deposit":"85f84934-0568-4083-9dd2-e1e21502c675"},"_deposit":{"created_by":11,"id":"3604","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"3604"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00003604","sets":["19:219:220","19:34:35","19:82:83"]},"author_link":["2568","6523","6393","7976","7973","4059","7474","7626","2545","6171","6506","7975","4000","1957","6470"],"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"60","bibliographicPageStart":"45","bibliographicVolumeNumber":"75","bibliographic_titles":[{},{"bibliographic_title":"Journal of Alzheimer's disease : JAD","bibliographic_titleLang":"en"}]}]},"item_4_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"清田, 弥寿成"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"守村, 敏史"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"渡邊, 直希"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"岩谷, 千鶴"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"土屋, 英明"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"中村, 紳一郎"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"柳沢, 大治郎 "}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"築山, 智之"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"中家, 雅隆"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"岡村, 永一"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"武藤, 真長"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"西村, 正樹"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"遠山, 育夫"}],"nameIdentifiers":[{},{},{}]}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Alzheimer's disease (AD) is the most common cause of dementia and understanding its pathogenesis should lead to improved therapeutic and diagnostic methods. Although several groups have developed transgenic mouse models overexpressing the human amyloid-β precursor protein (APP) gene with AD mutations, with and without presenilin mutations, as well as APP gene knock-in mouse models, these animals display amyloid pathology but do not show neurofibrillary tangles or neuronal loss. This presumably is due to differences between the etiology of the aged-related human disease and the mouse models. Here we report the generation of two transgenic cynomolgus monkeys overexpressing the human gene for APP with Swedish, Artic, and Iberian mutations, and demonstrated expression of gene tagged green fluorescent protein marker in the placenta, amnion, hair follicles, and peripheral blood. We believe that these nonhuman primate models will be very useful to study the pathogenesis of dementia and AD. However, generated Tg monkeys still have some limitations. We employed the CAG promoter, which will promote gene expression in a non-tissue specific manner. Moreover, we used transgenic models but not knock-in models. Thus, the inserted transgene destroys endogenous gene(s) and may affect the phenotype(s). Nevertheless, it will be of great interest to determine whether these Tg monkeys will develop tauopathy and neurodegeneration similar to human AD.","subitem_description_type":"Abstract"}]},"item_4_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article","subitem_description_type":"Other"}]},"item_4_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"IOS Press"}]},"item_4_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"32250299","subitem_relation_type_select":"PMID"}}]},"item_4_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.3233/JAD-191081"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3233/jad-191081","subitem_relation_type_select":"DOI"}}]},"item_4_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"2020 – IOS Press and the authors."},{"subitem_rights":"This article is published online with Open Access and distributed under the terms of the Creative Commons Attribution Non-Commercial License (CC BY-NC 4.0)."}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1875-8908","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"SEITA, Yasunari"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"MORIMURA, Toshifumi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"WATANABE, Naoki"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"IWATANI, Chizuru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TSUCHIYA, Hideaki"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"NAKAMURA, Shinichiro"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"SUZUKI, Toshiharu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YANAGISAWA, Daijiro"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"TSUKIYAMA, Tomoyuki"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"NAKAYA, Masataka"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"OKAMURA, Eiichi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"MUTO, Masanaga"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"EMA, Masatsugu"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"NISHIMURA, Masaki"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"TOOYAMA, Ikuo"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-17"}],"displaytype":"detail","filename":"JAD-191081.pdf","filesize":[{"value":"3.7 MB"}],"format":"application/pdf","license_note":"© 2020 – IOS Press and the authors. All rights reserved\nThis article is published online with Open Access and distributed under the terms of the Creative Commons Attribution Non-Commercial License (CC BY-NC 4.0).","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JAD-191081","url":"https://shiga-med.repo.nii.ac.jp/record/3604/files/JAD-191081.pdf"},"version_id":"97a0e501-6067-426f-a381-16f7274ba5e0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Amyloid-beta protein precursor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"animal","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cryopreservation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"intracytoplasmic sperm injection (ICSI)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"primates","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"transgenic","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"vitrification","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"zygote","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Generation of Transgenic Cynomolgus Monkeys Overexpressing the Gene for Amyloid-β Precursor Protein.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Generation of Transgenic Cynomolgus Monkeys Overexpressing the Gene for Amyloid-β Precursor Protein."}]},"item_type_id":"4","owner":"11","path":["35","83","220"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-06-17"},"publish_date":"2020-06-17","publish_status":"0","recid":"3604","relation_version_is_last":true,"title":["Generation of Transgenic Cynomolgus Monkeys Overexpressing the Gene for Amyloid-β Precursor Protein."],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-06-19T12:18:24.441697+00:00"}