@article{oai:shiga-med.repo.nii.ac.jp:00003604,
 author = {清田, 弥寿成 and 守村, 敏史 and 渡邊, 直希 and 岩谷, 千鶴 and 土屋, 英明 and 中村, 紳一郎 and 柳沢, 大治郎 and 築山, 智之 and 中家, 雅隆 and 岡村, 永一 and 武藤, 真長 and 西村, 正樹 and 遠山, 育夫 and SEITA, Yasunari and MORIMURA, Toshifumi and WATANABE, Naoki and IWATANI, Chizuru and TSUCHIYA, Hideaki and NAKAMURA, Shinichiro and SUZUKI, Toshiharu and YANAGISAWA, Daijiro and TSUKIYAMA, Tomoyuki and NAKAYA, Masataka and OKAMURA, Eiichi and MUTO, Masanaga and EMA, Masatsugu and NISHIMURA, Masaki and TOOYAMA, Ikuo},
 issue = {1},
 journal = {Journal of Alzheimer's disease : JAD},
 month = {Jun},
 note = {Alzheimer's disease (AD) is the most common cause of dementia and understanding its pathogenesis should lead to improved therapeutic and diagnostic methods. Although several groups have developed transgenic mouse models overexpressing the human amyloid-β precursor protein (APP) gene with AD mutations, with and without presenilin mutations, as well as APP gene knock-in mouse models, these animals display amyloid pathology but do not show neurofibrillary tangles or neuronal loss. This presumably is due to differences between the etiology of the aged-related human disease and the mouse models. Here we report the generation of two transgenic cynomolgus monkeys overexpressing the human gene for APP with Swedish, Artic, and Iberian mutations, and demonstrated expression of gene tagged green fluorescent protein marker in the placenta, amnion, hair follicles, and peripheral blood. We believe that these nonhuman primate models will be very useful to study the pathogenesis of dementia and AD. However, generated Tg monkeys still have some limitations. We employed the CAG promoter, which will promote gene expression in a non-tissue specific manner. Moreover, we used transgenic models but not knock-in models. Thus, the inserted transgene destroys endogenous gene(s) and may affect the phenotype(s). Nevertheless, it will be of great interest to determine whether these Tg monkeys will develop tauopathy and neurodegeneration similar to human AD., Journal Article},
 pages = {45--60},
 title = {Generation of Transgenic Cynomolgus Monkeys Overexpressing the Gene for Amyloid-β Precursor Protein.},
 volume = {75},
 year = {2020}
}