@article{oai:shiga-med.repo.nii.ac.jp:00003491,
 author = {布施, 恵子 and 門田, 文 and 近藤, 慶子 and 森野, 勝太郎 and 藤吉, 朗 and 久松, 隆史 and 門脇, 紗也佳 and 宮澤, 伊都子 and 卯木, 智 and 前川, 聡 and 三浦, 克之 and 上島, 弘嗣 and FUSE, Keiko and KADOTA, Aya and KONDO, Keiko and MORINO, Katsutaro and FUJIYOSHI, Akira and HISAMATSU, Takashi and KADOWAKI, Sayaka and MIYAZAWA, Itsuko and UGI, Satoshi and MAEGAWA, Hiroshi and MIURA, Katsuyuki and UESHIMA, Hirotsugu and Shiga, Epidemiological Study of Subclinical Atherosclerosis (SESSA) Research Group},
 journal = {Diabetes research and clinical practice},
 month = {Jan},
 note = {AIMS:
Ectopic fat accumulation is related to insulin resistance and diabetes mellitus (DM). However, the effect of fatty liver on DM in non-obese individuals has not been clarified. We investigated whether liver fat accumulation assessed by computed tomography (CT) is associated with the incidence of DM., METHODS:
In a prospective population-based study, 640 Japanese men were followed up for 5 years. The liver to spleen (L/S) ratio of the CT attenuation value was used as the liver fat accumulation index. We calculated the odds ratio (OR) and 95% confidence interval (CI) for the DM incidence of per 1 standard deviation (SD) lower L/S and those of L/S < 1.0 compared with L/S ≥ 1.0, using logistic regression models., RESULTS:
Both per 1 SD lower L/S and L/S < 1.0 were significantly associated with a risk for DM incidence (1 SD lower L/S: OR = 1.57, 95%CI = 1.14-2.16; L/S < 1.0: OR = 2.27, 95%CI = 1.00-5.14). The relationship between L/S and incidence of DM was consistent in the obese and non-obese groups, with thresholds of BMI 25 kg/m2, waist circumference 85 cm, or visceral adipose tissue 100 cm2., CONCLUSIONS:
Liver fat accumulation assessed by CT was associated with the incidence of DM., Journal Article},
 title = {Liver fat accumulation assessed by computed tomography is an independent risk factor for diabetes mellitus in a population-based study: SESSA (Shiga Epidemiological Study of Subclinical Atherosclerosis).},
 volume = {160},
 year = {2020}
}