{"created":"2023-06-19T10:43:16.373011+00:00","id":3478,"links":{},"metadata":{"_buckets":{"deposit":"cbe16e6f-234c-4e38-a139-940deb6e9e0a"},"_deposit":{"created_by":11,"id":"3478","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"3478"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00003478","sets":["19:232:233"]},"author_link":["7663","700"],"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-11-27","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageStart":"e0225721","bibliographicVolumeNumber":"14","bibliographic_titles":[{},{"bibliographic_title":"PloS ONE","bibliographic_titleLang":"en"}]}]},"item_4_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"礒野, 高敬"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"洲崎, 雅史"}],"nameIdentifiers":[{}]}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Starvation-resistant renal cell carcinoma (RCC) cell lines are considered dormant-state cells that survive even under glucose starvation. The cellular biological and global transcriptional analysis using these cells identified potential markers of chemotherapy-resistant RCC and therapeutic agent candidates. Recently, we showed that ARL4C was a predictive biomarker for poor prognosis in patients with chemotherapy-resistant RCC by the global transcriptional analysis of patient primary tissues. The objective of this study was to identify the characteristics of chemotherapy-resistant RCC by the global transcriptional analysis of primary tissues of patients with RCC and RCC cell lines. The connective global transcriptional analysis showed that two starvation-resistant RCC cell lines, SW839 and KMRC-1, were strongly correlated to tissues of patients with chemotherapy-resistant RCC and showed high expressions of invasive- and proliferation-related genes. We found fibronectin (FN1) expression was a predictive biomarker in some patients with chemotherapy-resistant RCC, which especially correlated with two starvation-resistant RCC cell lines. These results indicate these cell lines emulate chemotherapy-resistant RCC and might be useful in the search for markers to predict poor prognosis and in the development of therapeutic agents and their index markers for chemotherapy-resistant RCCs.","subitem_description_type":"Abstract"}]},"item_4_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article","subitem_description_type":"Other"}]},"item_4_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Public Library of Science"}]},"item_4_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"31774870","subitem_relation_type_select":"PMID"}}]},"item_4_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1371/journal.pone.0225721"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1371/journal.pone.0225721","subitem_relation_type_select":"DOI"}}]},"item_4_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2019 Isono, Suzaki."}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1932-6203","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ISONO, Takahiro"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"SUZAKI, Masafumi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-12-13"}],"displaytype":"detail","filename":"journal.pone.0225721.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","license_note":"© 2019 Isono, Suzaki. \nThis is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and\nreproduction in any medium, provided the original author and source are credited.","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"journal.pone.0225721","url":"https://shiga-med.repo.nii.ac.jp/record/3478/files/journal.pone.0225721.pdf"},"version_id":"dd906afd-035e-43ef-a554-41132c5b256a"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-12-13"}],"displaytype":"detail","filename":"Supporting informationF.pdf","filesize":[{"value":"96.2 kB"}],"format":"application/pdf","license_note":"© 2019 Isono, Suzaki. \nThis is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and\nreproduction in any medium, provided the original author and source are credited.","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Supporting informationF","url":"https://shiga-med.repo.nii.ac.jp/record/3478/files/Supporting informationF.pdf"},"version_id":"045c499d-92b6-42c0-a8b5-aeea3105c73f"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Analysis of the characteristics of chemotherapy-resistant renal cell carcinomas based on global transcriptional analysis of their tissues and cell lines.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Analysis of the characteristics of chemotherapy-resistant renal cell carcinomas based on global transcriptional analysis of their tissues and cell lines."}]},"item_type_id":"4","owner":"11","path":["233"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-12-13"},"publish_date":"2019-12-13","publish_status":"0","recid":"3478","relation_version_is_last":true,"title":["Analysis of the characteristics of chemotherapy-resistant renal cell carcinomas based on global transcriptional analysis of their tissues and cell lines."],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-06-19T12:23:53.041488+00:00"}