@article{oai:shiga-med.repo.nii.ac.jp:00003464,
 author = {新田, 直樹 and 野﨑, 和彦 and NITTA, Naoki and SHITARA, Satoshi and NOZAKI, Kazuhiko},
 issue = {6},
 journal = {Neurologia medico-chirurgica},
 month = {Dec},
 note = {A 58-year-old woman presented with right supplementary motor area glioblastoma multiforme and deep venous thrombosis in her legs. The tumor was resected after temporary inferior vena cava filter placement, considering that increased thrombosis during and after the operation would cause fatal pulmonary embolism. After anticoagulation with unfractionated heparin, thrombocytopenia was aggravated, and computed tomography showed filter catheter-related thrombosis in the inferior vena cava. The diagnosis was heparin-induced thrombocytopenia, and argatroban and urokinase were administered. Thrombolysis with urokinase was completed and the temporary inferior vena cava filter catheter was removed without complication. The present case illustrates the possibility of heparin-induced thrombocytopenia associated with catheter-related thrombosis in neurosurgery., 症例は左上下肢の進行性虚弱を主訴とする58歳女性で、造影MRIで右補足運動野に腫瘤(多形性神経膠芽細胞腫)、造影CTで両下肢に小さな血栓および下大静脈二つを認めた。術中および術後に血栓症が増大して致死的な肺塞栓症が生じる可能性があるため、下大静脈にフィルターを一時的に留置してから腫瘍を切除した。未分画ヘパリンによる抗凝固療法を施行したところ、血小板減少症が増悪し、CTで下大静脈にフィルターカテーテルに関連した血栓が認められた。ヘパリン誘発性血小板減少症と診断し、アルガトロバンおよびウロキナーゼを投与した。ウロキナーゼにより血栓が溶解され、フィルターカテーテルを合併症なしに除去できた。神経手術ではカテーテルに関連した血栓を伴うヘパリン誘発性血小板減少症が生じる可能性がある。, Journal Article},
 pages = {445--448},
 title = {Heparin-induced thrombocytopenia in a glioblastoma multiforme patient with inferior vena cava filter placement for deep venous thrombosis.},
 volume = {51},
 year = {2011}
}