{"created":"2023-06-19T10:43:15.366650+00:00","id":3455,"links":{},"metadata":{"_buckets":{"deposit":"e912ebb4-58ad-434d-931d-43a6321cc5de"},"_deposit":{"created_by":11,"id":"3455","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"3455"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00003455","sets":["19:34:35"]},"author_link":["7630","7626","7628","7629","1957","7242","7627","7631","7552"],"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-10-29","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"246","bibliographicPageStart":"229","bibliographicVolumeNumber":"72","bibliographic_titles":[{},{"bibliographic_title":"Journal of Alzheimer's Disease","bibliographic_titleLang":"en"}]}]},"item_4_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"柳沢, 大治郎 "}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"遠山, 育夫"}],"nameIdentifiers":[{},{},{}]}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Tocotrienol-rich fraction (TRF) is a mixture of vitamin E analogs derived from palm oil. We previously\ndemonstrated that supplementation with TRF improved cognitive function and modulated amyloid pathology in AβPP/PS1 mice brains. The current study was designed to examine proteomic profiles underlying the therapeutic effect of TRF in the brain. Proteomic analyses were performed on samples of hippocampus, medial prefrontal cortex (mPFC), and striatum using liquid chromatography coupled to Q Exactive HF Orbitrap mass spectrometry. From these analyses, we profiled a total of 5,847 proteins of which 155 proteins were differentially expressed between AβPP/PS1 and wild-type mice. TRF supplementation of these mice altered the expression of 255 proteins in the hippocampus, mPFC, and striatum. TRF also negatively modulated the expression of amyloid beta A4 protein and receptor-type tyrosine-protein phosphatase alpha protein in the hippocampus. The expression of proteins in metabolic\npathways, oxidative phosphorylation, and those involved in Alzheimer's disease were altered in the brains of AβPP/PS1 mice that received TRF supplementation.","subitem_description_type":"Abstract"}]},"item_4_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article","subitem_description_type":"Other"}]},"item_4_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"IOS Press"}]},"item_4_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"31594216","subitem_relation_type_select":"PMID"}}]},"item_4_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.3233/JAD-181171"}],"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3233/JAD-181171","subitem_relation_type_select":"DOI"}}]},"item_4_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2019 – IOS Press and the authors. All rights reserved"}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1387-2877","subitem_source_identifier_type":"ISSN"}]},"item_4_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11545428","subitem_source_identifier_type":"NCID"}]},"item_4_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hamezah, Hamizah Shahirah Binti"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Durani, Lina Wati Binti"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YANAGISAWA, Daijiro"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Ibrahim, Nor Faeizah"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Aizat, Wan Mohd"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Makpol, Suzana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wan Ngah, Wan Zurinah"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Damanhur, Hanafi Ahmad"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TOOYAMA, Ikuo"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-11-25"}],"displaytype":"detail","filename":"JAD-181171.pdf","filesize":[{"value":"748.2 kB"}],"format":"application/pdf","license_note":"© 2019 – IOS Press and the authors. All rights reserved\nThis article is published online with Open Access and distributed under the terms \nof the Creative Commons Attribution Non-Commercial License (CC BY-NC 4.0).","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JAD-181171","url":"https://shiga-med.repo.nii.ac.jp/record/3455/files/JAD-181171.pdf"},"version_id":"dae9aa3a-ab6b-40f2-8a2c-8b70fd3f8c48"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-11-25"}],"displaytype":"detail","filename":"Supplementary Materials.zip","filesize":[{"value":"12.4 MB"}],"format":"application/x-zip-compressed","license_note":"© 2019 – IOS Press and the authors. All rights reserved\nThis article is published online with Open Access and distributed under the terms \nof the Creative Commons Attribution Non-Commercial License (CC BY-NC 4.0).","licensetype":"license_note","mimetype":"application/zip","url":{"label":"Supplementary Materials","url":"https://shiga-med.repo.nii.ac.jp/record/3455/files/Supplementary Materials.zip"},"version_id":"9c4b5b3c-0635-4e7b-b2f5-7d9735b46e1f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Alzheimer’s disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"LC-MS","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"palm oil","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"proteomics","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"tocotrienol","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Modulation of Proteome Profile in AβPP/PS1 Mice Hippocampus, Medial Prefrontal Cortex, and Striatum by Palm Oil Derived Tocotrienol-Rich Fraction.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Modulation of Proteome Profile in AβPP/PS1 Mice Hippocampus, Medial Prefrontal Cortex, and Striatum by Palm Oil Derived Tocotrienol-Rich Fraction."}]},"item_type_id":"4","owner":"11","path":["35"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-11-25"},"publish_date":"2019-11-25","publish_status":"0","recid":"3455","relation_version_is_last":true,"title":["Modulation of Proteome Profile in AβPP/PS1 Mice Hippocampus, Medial Prefrontal Cortex, and Striatum by Palm Oil Derived Tocotrienol-Rich Fraction."],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-06-19T12:24:43.869793+00:00"}