{"created":"2023-06-19T10:43:15.323182+00:00","id":3454,"links":{},"metadata":{"_buckets":{"deposit":"3cdbcf46-16c6-4596-9aa8-df8bc347466b"},"_deposit":{"created_by":11,"id":"3454","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"3454"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00003454","sets":["30:89:90"]},"author_link":["6731","6179","7557"],"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-10-23","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageStart":"1620","bibliographicVolumeNumber":"11","bibliographic_titles":[{},{"bibliographic_title":"Cancers","bibliographic_titleLang":"en"}]}]},"item_4_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"清水, 昭男"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"扇田, 久和"}],"nameIdentifiers":[{},{},{}]}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The members of the family of epithelial membrane proteins (EMPs), EMP1, EMP2, and EMP3, possess four putative transmembrane domain structures and are composed of approximately 160 amino acid residues. EMPs are encoded by the growth arrest-specific 3 (GAS3)/peripheral myelin protein 22 kDa (PMP22) gene family. The GAS3/PMP22 family members play roles in cell migration, growth, and differentiation. Evidence indicates an association of these molecules with cancer progression and metastasis. Each EMP has pro- and anti-metastatic functions that are likely involved in the complex mechanisms of cancer progression. We have recently demonstrated that the upregulation of EMP1 expression facilitates cancer cell migration and invasion through the activation of a small GTPase, Rac1. The inoculation of prostate cancer cells overexpressing EMP1 into nude mice leads to metastasis to the lymph nodes and lungs, indicating that EMP1 contributes to metastasis. Pro-metastatic properties of EMP2 and EMP3 have also been proposed. Thus, targeting EMPs may provide new insights into their clinical utility. Here, we highlight the important aspects of EMPs in cancer biology, particularly invasiveness and metastasis, and describe recent therapeutic approaches.","subitem_description_type":"Abstract"}]},"item_4_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article","subitem_description_type":"Other"}]},"item_4_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"31652725","subitem_relation_type_select":"PMID"}}]},"item_4_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.3390/cancers11111620"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3390/cancers11111620","subitem_relation_type_select":"DOI"}}]},"item_4_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2019 by the authors."}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2072-6694","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ahmat Amin, Mohammad Khusni Bin"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"SHIMIZU, Akio"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"扇田, 久和"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-11-20"}],"displaytype":"detail","filename":"cancers11111620.pdf","filesize":[{"value":"1.8 MB"}],"format":"application/pdf","license_note":"© 2019 by the authors. \nLicensee MDPI, Basel, Switzerland. \nThis article is an open access article distributed under the terms and conditions \nof the Creative Commons Attribution (CC BY) license \n(http://creativecommons.org/licenses/by/4.0/).","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"cancers11111620","url":"https://shiga-med.repo.nii.ac.jp/record/3454/files/cancers11111620.pdf"},"version_id":"48e4e367-604e-4f67-97bc-2d07b5a92a71"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"apoptosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cancer progression","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cell migration","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cell proliferation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"transmembrane protein","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The Pivotal Roles of the Epithelial Membrane Protein Family in Cancer Invasiveness and Metastasis.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The Pivotal Roles of the Epithelial Membrane Protein Family in Cancer Invasiveness and Metastasis."}]},"item_type_id":"4","owner":"11","path":["90"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-11-20"},"publish_date":"2019-11-20","publish_status":"0","recid":"3454","relation_version_is_last":true,"title":["The Pivotal Roles of the Epithelial Membrane Protein Family in Cancer Invasiveness and Metastasis."],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-06-19T11:12:47.885169+00:00"}