@article{oai:shiga-med.repo.nii.ac.jp:00003436,
 author = {HINO, Kodai and KANEKO, Shunya and HARASAWA, Toshiya and KIMURA, Tomoko and TAKEI, Shiro and SHINOHARA, Masakazu and YAMAZAKI, Fumiyoshi and 森田, 真也 and SATO, Shumpei and KUBO, Yoshihito and KONO, Tadaaki and SETOU, Mitsutoshi and YOSHIOKA, Mina and FUJINO, Junya and SUGIHARA, Hiroyuki and KOJIMA, Hideto and YAMADA, Naoto and UDAGAWA, Jun},
 journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
 month = {Aug},
 note = {Epidemiological studies suggest that poor nutrition during pregnancy influences offspring predisposition to experience developmental and psychiatric disorders. Animal studies have shown that maternal undernutrition leads to behavioral impairment, which is linked to alterations in monoaminergic systems and inflammation in the brain. In this study, we focused on the ethanolamine plasmalogen of the brain as a possible contributor to behavioral disturbances observed in offspring exposed to maternal undernutrition. Maternal food or protein restriction between gestational day (GD) 5.5 and GD 10.5 resulted in hyperactivity of rat male adult offspring. Genes related to the phospholipid biosynthesis were found to be activated in the prefrontal cortex (PFC), but not in the nucleus accumbens or striatum, in the offspring exposed to prenatal undernutrition. Corresponding to these gene activations, increased ethanolamine plasmalogen (18:0p-22:6) was observed in the PFC using mass spectrometry imaging. A high number of crossings and the long time spent in the center area was observed in the offspring exposed to prenatal undernutrition and was mimicked in adult rats via the intravenous injection of ethanolamine plasmalogen (18:0p-22:6) incorporated into the liposome. Additionally, plasmalogen (18:0p-22:6) increased only in the PFC, and not in the nucleus accumbens or striatum. These results suggest that brain plasmalogen is one of the key molecules to control behavior and its injection using liposome is a potential therapeutic approach for cognitive impairment., Significance Statement:
Maternal undernutrition correlates to developmental and psychiatric disorders. Here, we found that maternal undernutrition in early pregnancy led to hyperactivity in rat male offspring and induced gene activation of phospholipid-synthesizing enzyme and elevation of ethanolamine plasmalogen (18:0p-22:6) level in the prefrontal cortex (PFC). Intravenous injection of ethanolamine plasmalogen (18:0p-22:6) incorporated into the liposome maintained crossing activity and was circumscribed to the center area for a long time period, in prenatally undernourished offspring with aberrant behavior. Furthermore, the amount of ethanolamine plasmalogen (18:0p-22:6) increased in the PFC of the rat after injection. Our result suggests that brain plasmalogen is one of the key molecules to control behavior and that its injection using liposome is a potential therapeutic approach for cognitive impairment., Journal Article},
 title = {Change in brain plasmalogen composition by exposure to prenatal undernutrition leads to behavioral impairment of rats.},
 year = {2019}
}