@article{oai:shiga-med.repo.nii.ac.jp:00003331,
 author = {井上, 明星 and 古川, 顕 and 山本, 寛 and OHTA, Shinichi and 貝田, 佐知子 and 山口, 剛 and 村田, 聡 and 小幡, 徹 and 谷, 眞至 and 村田, 喜代史 and Inoue, Akitoshi and FURUKAWA, Akira and YAMAMOTO, Hiroshi and OHTA, Shinichi and Linh, Nguyen Dai Hung and Syerikjan, Tulyeubai and KAIDA, Sachiko and YAMAGUCHI, Tsuyoshi and MURATA, Satoshi and OBATA, Toru and TANI, Masaji and MURATA, Kiyoshi},
 issue = {1},
 journal = {PLoS ONE},
 month = {Jan},
 note = {Dai-kenchu-to (TJ-100) is an herbal medicine used to shorten the duration of intestinal transit by accelerating intestinal movement. However, intestinal movement in itself has not been evaluated in healthy volunteers using radiography, fluoroscopy, and radioisotopes because of exposure to ionizing radiation. The purpose of this study was to evaluate the effect of TJ-100 on intestinal motility using cinematic magnetic resonance imaging (cine MRI) with a steady-state free precession sequence. Ten healthy male volunteers received 5 g of either TJ-100 or lactose without disclosure of the identity of the substance. Each volunteer underwent two MRI examinations after taking the substances (TJ-100 and lactose) on separate days. They drank 1200 mL of tap water and underwent cine MRI after 10 min. A steady-state free precession sequence was used for imaging, which was performed thrice at 0, 10, 20, 30, 40, and 50 min. The bowel contraction frequency and distention score were assessed. Wilcoxon signed-rank test was used, and differences were considered significant at a P-value <0.05. The bowel contraction frequency tended to be greater in the TJ-100 group and was significantly different in the ileum at 20 (TJ-100, 8.95 ± 2.88; lactose, 4.80 ± 2.92; P < 0.05) and 50 min (TJ-100, 9.45 ± 4.49; lactose, 4.45 ± 2.65; P < 0.05) between the groups. No significant differences were observed in the bowel distention scores. Cine MRI demonstrated that TJ-100 activated intestinal motility without dependence on ileum distention., Journal Article},
 title = {Acceleration of small bowel motility after oral administration of dai-kenchu-to (TJ-100) assessed by cine magnetic resonance imaging.},
 volume = {13},
 year = {2018}
}