{"created":"2023-06-19T10:43:09.932107+00:00","id":3325,"links":{},"metadata":{"_buckets":{"deposit":"f9624899-508c-4dc7-9e81-8037087b5502"},"_deposit":{"created_by":11,"id":"3325","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"3325"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00003325","sets":["30:211:212"]},"author_link":["7391","7398","7395","7390","7396","7400","7399","7394","6474","7392","7397","7393"],"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-04-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageStart":"e1602663","bibliographicVolumeNumber":"3","bibliographic_titles":[{"bibliographic_title":"Science Advances"}]}]},"item_4_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"14202","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"KADOTANI, Hiroshi","creatorNameLang":"en"},{"creatorName":"角谷, 寛","creatorNameLang":"ja"},{"creatorName":"カドタニ, ヒロシ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"KADOTANI","familyNameLang":"en"},{"familyName":"角谷","familyNameLang":"ja"},{"familyName":"カドタニ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Hiroshi","givenNameLang":"en"},{"givenName":"寛","givenNameLang":"ja"},{"givenName":"ヒロシ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{},{},{}]}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Sleep is found widely in the animal kingdom. Despite this, few conserved molecular pathways that govern sleep across phyla have been described. The mammalian brain-type fatty acid binding protein (Fabp7) is expressed in astrocytes, and its mRNA oscillates in tandem with the sleep-wake cycle. However, the role of FABP7 in regulating sleep remains poorly understood. We found that the missense mutation FABP7.T61M is associated with fragmented sleep in humans. This phenotype was recapitulated in mice and fruitflies bearing similar mutations: Fabp7-deficient mice and transgenic flies that express the FABP7.T61M missense mutation in astrocytes also show fragmented sleep. These results provide novel evidence for a distinct molecular pathway linking lipid-signaling cascades within astrocytes in sleep regulation among phylogenetically disparate species.","subitem_description_type":"Abstract"}]},"item_4_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article","subitem_description_type":"Other"}]},"item_4_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"American Association for the Advancement of Science"}]},"item_4_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"28435883","subitem_relation_type_select":"PMID"}}]},"item_4_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1126/sciadv.1602663","subitem_relation_type_select":"DOI"}}]},"item_4_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"2017© The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC)."}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2375-2548","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Gerstner, Jason R"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Perron, Isaac J"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Riedy, Samantha M"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshikawa, Takeo"}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"14202","affiliationNameIdentifierScheme":"kakenhi"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"KADOTANI, Hiroshi","creatorNameLang":"en"},{"creatorName":"角谷, 寛","creatorNameLang":"ja"},{"creatorName":"カドタニ, ヒロシ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"KADOTANI","familyNameLang":"en"},{"familyName":"角谷","familyNameLang":"ja"},{"familyName":"カドタニ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Hiroshi","givenNameLang":"en"},{"givenName":"寛","givenNameLang":"ja"},{"givenName":"ヒロシ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Owada, Yuji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Van Dongen, Hans PA"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Galante, Raymond J"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Dickinson, Kaitlin"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yin, Jerry CP"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Pack, Allan I"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Frank, Marcos G"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-11-05"}],"displaytype":"detail","filename":"sciadv.1602663.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensetype":"license_9","mimetype":"application/pdf","url":{"label":"sciadv.1602663","url":"https://shiga-med.repo.nii.ac.jp/record/3325/files/sciadv.1602663.pdf"},"version_id":"bcf2fca6-fc2a-4585-87d0-9f331a8925e9"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Animals","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Astrocytes","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Biological Clocks","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Brain","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Drosophila melanogaster","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Fatty Acid-Binding Protein 7","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Female","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Humans","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Male","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Mice","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Mice, Knockout","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Mutation, Missense","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Signal Transduction","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Sleep","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Tumor Suppressor Proteins","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Normal sleep requires the astrocyte brain-type fatty acid binding protein FABP7.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Normal sleep requires the astrocyte brain-type fatty acid binding protein FABP7."}]},"item_type_id":"4","owner":"11","path":["212"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-11-05"},"publish_date":"2018-11-05","publish_status":"0","recid":"3325","relation_version_is_last":true,"title":["Normal sleep requires the astrocyte brain-type fatty acid binding protein FABP7."],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-07-24T11:31:47.609507+00:00"}