@article{oai:shiga-med.repo.nii.ac.jp:00003295,
 author = {宮川, 尚子 and 齋藤, 祥乃 and 中村, 保幸 and 門田, 文 and 上島, 弘嗣 and 三浦, 克之 and Shibata, Yosuke and Ojima, Toshiyuki and NAKAMURA, Mieko and Kuwabara, Kazuyo and MIYAGAWA, Naoko and SAITO, Yoshino and NAKAMURA, Yasuyuki and Kiyohara, Yutaka and Nakagawa, Hideaki and FUJIYOSHI, Akira and KADOTA, Aya and OHKUBO, Takayoshi and OKAMURA, Tomonori and UESHIMA, Hirotsugu and 岡山, 明 and MIURA, Katsuyuki},
 journal = {Journal of Epidemiology},
 month = {Jul},
 note = {BACKGROUND:
The trend of association between overweight and high serum total cholesterol (TC)
among the elderly is unclear. In addition, there is little evidence of risk of underweight
for high TC. Therefore, we examined the trend of association of overweight or 
underweight with high TC among Japanese elderly people using nationwide population-
based data., METHODS:
Data of the National Survey on Circulatory Disorders and National Health and Nutrition
Survey for 1980, 1990, 2000, and 2010 were used in the analysis. High TC was defined
as 220 mg/dL and above. For participants aged ≥50 years, sex-specific odds ratios (ORs)
of overweight or underweight compared with normal body mass index participants for
high TC were calculated using a logistic regression model adjusted for age, smoking, 
drinking, exercise, food, and treatment of hyperlipidemia., RESULTS:
A total of 5,014, 4,673, 5,059, and 2,105 participants enrolled in these surveys in 1980,
1990, 2000, and 2010, respectively. Although overweight was positively and significantly
associated with high TC in 1980, the association has gradually weakened since (ORs in 
1980 and 2010 were 2.44; 95% confidence interval [CI], 1.83-3.24 and 0.92; 95% CI, 
0.66-1.27 among men and 1.43; 95% CI, 1.18-1.72 and 1.08; 95% CI, 0.81-1.44 
among women, respectively). While underweight was inversely and significantly
associated with high TC in 1980, the association also gradually weakened among women
(ORs in 1980 and 2010 were 0.28; 95% CI, 0.12-0.60 and 0.37; 95% CI, 0.10-1.28 
among men and 0.39; 95% CI, 0.26-0.57 and 0.96; 95% CI, 0.58-1.57 among women,
respectively)., CONCLUSIONS:
These findings provide evidence that high TC prevention efforts must expand the target 
to not only overweight but also to normal and underweight people., Journal Article},
 title = {Associations of Overweight, Obesity, and Underweight With High Serum Total Cholesterol Level Over 30 Years Among the Japanese Elderly: NIPPON DATA 80, 90, and 2010.},
 year = {2018}
}