@article{oai:shiga-med.repo.nii.ac.jp:00003214,
 author = {石垣, 宏仁 and 伊藤, 靖 and 小笠原, 一誠 and Morizane, Asuka and Kikuchi, Tetsuhiro and Hayashi, Takuya and Mizuma, Hiroshi and Takara, Sayuki and Doi, Hisashi and Mawatari, Aya and Glasser, Matthew F and Shiina, Takashi and ISHIGAKI, Hirohito and Itoh, Yasushi and Okita, Keisuke and Yamasaki, Emi and Doi, Daisuke and Onoe, Hirotaka and OGASAWARA, Kazumasa and Yamanaka, Shinya and Takahashi, Jun},
 issue = {1},
 journal = {Nature Communications},
 month = {Aug},
 note = {The banking of human leukocyte antigen (HLA)-homozygous-induced pluripotent stem cells (iPSCs) is considered a future clinical strategy for HLA-matched cell transplantation to reduce immunological graft rejection. Here we show the efficacy of major histocompatibility complex (MHC)-matched allogeneic neural cell grafting in the brain, which is considered a less immune-responsive tissue, using iPSCs derived from an MHC homozygous cynomolgus macaque. Positron emission tomography imaging reveals neuroinflammation associated with an immune response against MHC-mismatched grafted cells. Immunohistological analyses reveal that MHC-matching reduces the immune response by suppressing the accumulation of microglia (Iba-1+) and lymphocytes (CD45+) into the grafts. Consequently, MHC-matching increases the survival of grafted dopamine neurons (tyrosine hydroxylase: TH+). The effect of an immunosuppressant, Tacrolimus, is also confirmed in the same experimental setting. Our results demonstrate the rationale for MHC-matching in neural cell grafting to the brain and its feasibility in a clinical setting.Major histocompatibility complex (MHC) matching improves graft survival rates after organ transplantation. Here the authors show that in macaques, MHC-matched iPSC-derived neurons provide better engraftment in the brain, with a lower immune response and higher survival of the transplanted neurons., Journal Article},
 title = {MHC matching improves engraftment of iPSC-derived neurons in non-human primates.},
 volume = {8},
 year = {2017}
}