{"created":"2023-06-19T10:43:01.858518+00:00","id":3135,"links":{},"metadata":{"_buckets":{"deposit":"603b6132-b993-4650-8458-9037456ee31a"},"_deposit":{"created_by":11,"id":"3135","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"3135"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00003135","sets":["6:7:115:116"]},"author_link":["6843","1957"],"item_3_alternative_title_18":{"attribute_name":"その他の言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Possible function of Reelin-Dab1 signal to mitigate Alzheimer’s disease"}]},"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-02-27","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"32","bibliographicPageStart":"27","bibliographicVolumeNumber":"30","bibliographic_titles":[{"bibliographic_title":"滋賀医科大学雑誌"}]}]},"item_3_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Departmental Bulletin Paper ","subitem_description_type":"Other"}]},"item_3_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Accumulation of amyloid-β peptides (Aβ) proteolytically produced from amyloid precursor protein is the strong candidate of pathological cause of Alzheimer’s disease (AD). Recent studies suggest that soluble Aβ including oligomers affect synaptic function of neurons in AD pathogenesis. Although Reelin-Dab1 signal has been well studied in the context of brain morphogenesis during development, its involvement in psychiatric diseases was recently suggested from human genome studies as well as animal and biochemical experimental studies. Especially, it has been reported that the molecules of Reelin-Dab1 signal are involved in AD pathogenesis. Here, we review these studies and discuss Reelin-Dab1 signal as a possible therapeutic target of AD.","subitem_description_type":"Other"}]},"item_3_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"滋賀医科大学雑誌編集委員会"}]},"item_3_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0912-3016","subitem_source_identifier_type":"ISSN"}]},"item_3_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"勝山, 裕"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"遠山, 育夫"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-06-13"}],"displaytype":"detail","filename":"jsums3001p027.pdf","filesize":[{"value":"678.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"jsums3001p027","url":"https://shiga-med.repo.nii.ac.jp/record/3135/files/jsums3001p027.pdf"},"version_id":"87bcc4d6-d1de-4718-8ba9-b0341f3e3276"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Reelin-Dab1シグナル","subitem_subject_scheme":"Other"},{"subitem_subject":"アルツハイマー病","subitem_subject_scheme":"Other"},{"subitem_subject":"アミロイドペプチドβ","subitem_subject_scheme":"Other"},{"subitem_subject":"加齢","subitem_subject_scheme":"Other"},{"subitem_subject":"モデルマウス","subitem_subject_scheme":"Other"},{"subitem_subject":"Reelin-Dab1 signal","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Alzheimer’s disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"amyloid peptideβ","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"aging","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"model mouse","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Reelin-Dab1シグナルのアルツハイマー病発症抑制機能","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Reelin-Dab1シグナルのアルツハイマー病発症抑制機能"}]},"item_type_id":"3","owner":"11","path":["116"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-06-13"},"publish_date":"2017-06-13","publish_status":"0","recid":"3135","relation_version_is_last":true,"title":["Reelin-Dab1シグナルのアルツハイマー病発症抑制機能"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-06-19T12:23:17.870321+00:00"}