{"created":"2023-06-19T10:42:57.633338+00:00","id":3026,"links":{},"metadata":{"_buckets":{"deposit":"8d47dc97-b11a-4a06-8f7c-31506ce35a4e"},"_deposit":{"created_by":3,"id":"3026","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3026"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00003026","sets":["30:89:90"]},"author_link":["6733","6732","6179","6731","1863"],"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-01-03","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"39335","bibliographicVolumeNumber":"7","bibliographic_titles":[{"bibliographic_title":"Scientific Reports"}]}]},"item_4_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"清水, 昭男"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"扇田, 久和"}],"nameIdentifiers":[{},{},{}]}]},"item_4_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"pdf","subitem_description_type":"Other"}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Adhesive intercellular connections at cardiomyocyte intercalated disks (IDs) support contractile force and maintain structural integrity of the heart muscle. Disturbances of the proteins at IDs deteriorate cardiac function and morphology. An adaptor protein afadin, one of the components of adherens junctions, is expressed ubiquitously including IDs. At present, the precise role of afadin in cardiac physiology or disease is unknown. To explore this, we generated conditional knockout (cKO) mice with cardiomyocyte-targeted deletion of afadin. Afadin cKO mice were born according to the expected Mendelian ratio and have no detectable changes in cardiac phenotype. On the other hand, chronic pressure overload induced by transverse aortic constriction (TAC) caused systolic dysfunction, enhanced fibrogenesis and apoptosis in afadin cKO mice. Afadin deletion increased macrophage infiltration and monocyte chemoattractant protein-1 expression, and suppressed transforming growth factor (TGF) β receptor signaling early after TAC procedure. Afadin also associated with TGFβ receptor I at IDs. Pharmacological antagonist of TGFβ receptor I (SB431542) augmented mononuclear infiltration and fibrosis in the hearts of TAC-operated control mice. In conclusion, afadin is a critical molecule for cardiac protection against chronic pressure overload. The beneficial effects are likely to be a result from modulation of TGFβ receptor signaling pathways by afadin. ","subitem_description_type":"Abstract"}]},"item_4_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Journal Article","subitem_description_type":"Other"}]},"item_4_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nature Publishing Group"}]},"item_4_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"28045017","subitem_relation_type_select":"PMID"}}]},"item_4_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1038/srep39335"}],"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1038/srep39335","subitem_relation_type_select":"DOI"}}]},"item_4_relation_13":{"attribute_name":"PMCID","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"PMC5206728"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.ncbi.nlm.nih.gov/pmc/articles/pmc5206728/","subitem_relation_type_select":"URI"}}]},"item_4_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© The Author(s) 2017"}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2045-2322","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ZANKOV, Dimitar Petrov"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SHIMIZU, Akio"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"TANAKA-OKAMOTO, Miki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MIYOSHI, Jun"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"扇田, 久和"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-17"}],"displaytype":"detail","filename":"srep39335.pdf","filesize":[{"value":"4.1 MB"}],"format":"application/pdf","license_note":"This work is licensed under a Creative Commons Attribution 4.0 International License. The images\nor other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license,\nusers will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit \nhttp://creativecommons.org/licenses/by/4.0/","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"srep39335.pdf","url":"https://shiga-med.repo.nii.ac.jp/record/3026/files/srep39335.pdf"},"version_id":"b9bfaf29-cfc4-461d-b336-c058679c577b"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Protective effects of intercalated disk protein afadin on chronic pressure overload-induced myocardial damage.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Protective effects of intercalated disk protein afadin on chronic pressure overload-induced myocardial damage."}]},"item_type_id":"4","owner":"3","path":["90"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-01-11"},"publish_date":"2017-01-11","publish_status":"0","recid":"3026","relation_version_is_last":true,"title":["Protective effects of intercalated disk protein afadin on chronic pressure overload-induced myocardial damage."],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-19T11:12:42.344342+00:00"}