@phdthesis{oai:shiga-med.repo.nii.ac.jp:00002916,
 author = {VIGERS, Piers Nigel},
 month = {May},
 note = {Objective: Briefly to compare twin and multiple regions of interest (ROIs) in structural magnetic resonance images (sMRI), testing two statistical parametric mapping (SPM) packages against amyloid status in patients diagnosed with mild cognitive impairment (MCI), who underwent positron emission tomography with Pittsburg compound B (PiB-PET). The packages were Voxel-based specific regional analysis system for Alzheimer’s disease (VSRAD) and Brain anatomical analysis using DARTEL (BAAD). Subject data: Data on 65 patients diagnosed with MCI, who had undergone both sMRI scans and PiB-PET beta-amyloid imaging, were downloaded from the Alzheimer's disease neuroimaging initiative (ADNI) database. Of those 65 MCI cases, 18 were found positive by PiB-PET. Data Processing: BAAD interprets sMRI both in false-color images and in Z-scores for 98 brain regions. VSRAD also gives a false-color picture, and one bilateral-twin-ROI z-score, usually for the region of the hippocampus and entorhinal cortex, with ROI-locations specified in MNI coordinates. Results: Receiver operating characteristic (ROC) curves were used to measure the reliability of each set of ROIs by the area under the curve (AUC). VSRAD gave AUC around 0.68 with its default ROIs in the medial temporal lobe. With BAAD, AUC figures depended on the ROIs chosen; AUC values ranged from 0.69 for the hippocampal regions, via 0.86 for 16 (bilateral) ROIs, to 0.98 or more with empirically selected (mostly unilateral) ROIs, not all contiguous. Conclusions: Our results indicated that the multi-ROI approach offers greater versatility and better discrimination of the amyloid-positive MCI cases, improving the prospect of data-acquisition and diagnosis earlier than the MCI stage. Both the number and selection of ROIs are crucial to accuracy. Further testing will be needed to validate ROI combinations for MCI and earlier stages, for other populations and pathologies, and for mixed pathologies., Thesis or Dissertation, 平成27年度},
 school = {滋賀医科大学},
 title = {Diagnosis of amyloid-positive mild cognitive impairment using structural magnetic resonance imaging : The worth of multiple regions of interest.},
 year = {2015}
}