{"created":"2025-03-12T04:39:25.811350+00:00","id":2000426,"links":{},"metadata":{"_buckets":{"deposit":"a0cceaf6-4e06-4a69-89cf-9561717580e0"},"_deposit":{"created_by":11,"id":"2000426","owner":"11","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"2000426"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:02000426","sets":["77:78:79"]},"author_link":["4010","4010"],"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-05-11","bibliographicIssueDateType":"Issued"},"bibliographicNumberOfPages":"14","bibliographicVolumeNumber":"10","bibliographic_titles":[{"bibliographic_title":"Journal of pharmaceutical health care and sciences","bibliographic_titleLang":"en"}]}]},"item_4_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"森田, 真也","creatorNameLang":"ja","creatorNameType":"Personal"},{"creatorName":"モリタ, シンヤ","creatorNameLang":"ja-Kana","creatorNameType":"Personal"}],"nameIdentifiers":[{"nameIdentifier":"4010","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20449870","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20449870"},{"nameIdentifier":"0000-0003-4079-707X","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0003-4079-707X"}]}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Coronary heart disease, also known as ischemic heart disease, is induced by atherosclerosis, which is initiated by subendothelial retention of lipoproteins. Plasma lipoproteins, including high density lipoprotein, low density lipoprotein (LDL), very low density lipoprotein, and chylomicron, are composed of a surface monolayer containing phospholipids and cholesterol and a hydrophobic core containing triglycerides and cholesteryl esters. Phospholipids play a crucial role in the binding of apolipoproteins and enzymes to lipoprotein surfaces, thereby regulating lipoprotein metabolism. High LDL-cholesterol is a well-known risk factor for coronary heart disease, and statins reduce the risk of coronary heart disease by lowering LDL-cholesterol levels. In contrast, the relationships of phospholipids in plasma lipoproteins with coronary heart disease have not yet been established. To further clarify the physiological and pathological roles of phospholipids, we have developed the simple high-throughput assays for quantifying all major phospholipid classes, namely phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidic acid, phosphatidylinositol, phosphatidylglycerol + cardiolipin, and sphingomyelin, using combinations of specific enzymes and a fluorogenic probe. These enzymatic fluorometric assays will be helpful in elucidating the associations between phospholipid classes in plasma lipoproteins and coronary heart disease and in identifying phospholipid biomarkers. This review describes recent progress in the identification of phospholipid biomarkers of coronary heart disease.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_4_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"BioMed Central Ltd","subitem_publisher_language":"en"}]},"item_4_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"38734675","subitem_relation_type_select":"PMID"}}]},"item_4_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1186/s40780-024-00344-y","subitem_relation_type_select":"DOI"}}]},"item_4_relation_13":{"attribute_name":"PMCID","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11088770/","subitem_relation_type_select":"URI"}}]},"item_4_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2024. The Author(s).","subitem_rights_language":"en"},{"subitem_rights":"Creative Commons Attribution 4.0 International","subitem_rights_language":"en","subitem_rights_resource":"http://creativecommons.org/licenses/by/4.0/"}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2055-0294","subitem_source_identifier_type":"EISSN"}]},"item_4_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"MORITA, Shin-ya","creatorNameLang":"en","creatorNameType":"Personal"}],"nameIdentifiers":[{"nameIdentifier":"4010","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20449870","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20449870"},{"nameIdentifier":"0000-0003-4079-707X","nameIdentifierScheme":"ORCID","nameIdentifierURI":"https://orcid.org/0000-0003-4079-707X"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-03-12"}],"filename":"s40780-024-00344-y.pdf","filesize":[{"value":"1.9 MB"}],"format":"application/pdf","licensetype":"license_0","url":{"objectType":"fulltext","url":"https://shiga-med.repo.nii.ac.jp/record/2000426/files/s40780-024-00344-y.pdf"},"version_id":"6d9692fa-8459-4234-8644-c790e597ebdb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Phospholipid","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cholesterol","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Triglyceride","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Lipoprotein","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Coronary heart disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Atherosclerosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Enzymatic fluorometric assay","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Phosphatidylcholine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Sphingomyelin","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Phospholipid biomarkers of coronary heart disease","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Phospholipid biomarkers of coronary heart disease","subitem_title_language":"en"}]},"item_type_id":"4","owner":"11","path":["79"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2025-03-12"},"publish_date":"2025-03-12","publish_status":"0","recid":"2000426","relation_version_is_last":true,"title":["Phospholipid biomarkers of coronary heart disease"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2025-03-12T04:50:12.304976+00:00"}