{"created":"2023-06-19T10:40:38.428219+00:00","id":162,"links":{},"metadata":{"_buckets":{"deposit":"cfab5337-ada5-4515-bb61-bdd9f9552f81"},"_deposit":{"created_by":3,"id":"162","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"162"},"status":"published"},"_oai":{"id":"oai:shiga-med.repo.nii.ac.jp:00000162","sets":["6:7:125:126"]},"author_link":["561"],"item_3_alternative_title_18":{"attribute_name":"その他の言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Application of novel clinicopathological biomarkers"}]},"item_3_alternative_title_19":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"シンリョウ ニ オケル シンキ マーカー ノ タンサク ト テキヨウ （ダイ 8カイ キソ リンショウ ユウゴウ ノ ガクナイ キョウドウ ケンキュウ ハッピョウカイ）（ショウロク）"}]},"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-02-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"a28","bibliographicPageStart":"a26","bibliographicVolumeNumber":"26","bibliographic_titles":[{"bibliographic_title":"滋賀医科大学雑誌"}]}]},"item_3_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Departmental Bulletin Paper","subitem_description_type":"Other"}]},"item_3_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"To contribute the order-made medicine for cancer treatments, we have originally searched several biomarkers in thelast decade. Some have been used as immunohistochemically novel biomarkers for the cancer diagnosis, and the others haveapplied to molecular target for the cancer therapy. RB1-inducible coiled-coil 1 (RB1CC1; also known as FIP200) playsimportant roles in biological pathways such as cell cycle arrest and autophagy, and the nuclear expression has been establishedas a prognostic predictor in breast and salivary cancer patients. RECQL1 and WRN protein are RecQ DNA helicases thatparticipate in suppression of DNA hyper-recombination and repair. We have found that both proteins are highly expressed andthat siRNA-mediated silencing of either gene suppressed head and neck squamous cell carcinomas in vitro and in vivo. Thedata offer a preclinical proof-of-concept for RecQ proteins as novel therapeutic targets to treat aggressive head and necksquamous cell carcinomas. In testicular germ cell tumors, the fetal-specific methyltransferase-like protein DNMT3L isexpressed, and has been used as a novel marker of human embryonal carcinoma. Further elucidation of the roles of DNMT3Lin vivo warrants a possible significance as a therapeutic target of embryonal carcinoma. These novel biomarkers such asRB1CC1, RecQ, and DNMT3L provide new insight into cancer diagnosis and therapy; and will help to realize the order-mademedicine.","subitem_description_type":"Other"}]},"item_3_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"滋賀医科大学雑誌編集委員会"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"茶野, 徳宏"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-16"}],"displaytype":"detail","filename":"jsums2601pa26.pdf","filesize":[{"value":"270.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"jsums2601pa26.pdf","url":"https://shiga-med.repo.nii.ac.jp/record/162/files/jsums2601pa26.pdf"},"version_id":"5b141c7c-b1b8-472b-96e1-9cfb89f64aa8"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"診療に於ける新規マーカーの探索と適用（第8回基礎・臨床融合の学内共同研究発表会）（抄録）","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"診療に於ける新規マーカーの探索と適用（第8回基礎・臨床融合の学内共同研究発表会）（抄録）"}]},"item_type_id":"3","owner":"3","path":["126"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-04-12"},"publish_date":"2016-04-12","publish_status":"0","recid":"162","relation_version_is_last":true,"title":["診療に於ける新規マーカーの探索と適用（第8回基礎・臨床融合の学内共同研究発表会）（抄録）"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-19T12:27:57.795583+00:00"}