@article{oai:shiga-med.repo.nii.ac.jp:00000159,
 author = {小島, 秀人 and 樫, 美和子 and 寺島, 智也 and 前川, 聡 and 木村, 博},
 issue = {1},
 journal = {滋賀医科大学雑誌},
 month = {Feb},
 note = {Departmental Bulletin Paper, Diabetes therapy has dramatically progressed, but the chronic complications such as microvascular and macrovascularcomplications are still the important causes of morbidity and mortality rates in diabetic patients. Metabolic perturbations such as oxidativestress, advance glycation end product formation, protein kinase C and NFκB activation, increased polyol flux, and poly(ADP-ribose)polymerase-1 (PARP-1) activation play key roles in the onset of the chronic complications. However, the direct cause is not discovered. Thus,the treatments for the purpose to cure the complications are not established. Recently, we found bone marrow-derived cells that haveabnormal characteristics in their stem cell phase, and were related to the onset of the diabetic complications. Here we show some evidencesthat the abnormal bone marrow-derived cells were formed under the high-glucose toxic condition in the bone marrow stem cells, which wasproduced by diabetic hyperglycemia, and played a major role as an important pathogenesis of the chronic complications in diabetes mellitus.Based on those results, we will describe some strategies that lead to the development of new treatments against their evil characteristics ofthe diabetic bone marrow stem cells.},
 pages = {a14--a19},
 title = {糖尿病合併症を誘導する異常骨髄幹細胞の同定と新規治療の開発（第9回基礎・臨床融合の学内共同研究発表会）（抄録）},
 volume = {26},
 year = {2013}
}