@article{oai:shiga-med.repo.nii.ac.jp:00000157, author = {椎野, 顯彦 and 小島, 秀人 and 小松, 直樹 and 小畑, 利之 and 寺島, 智也 and 前川, 聡 and 犬伏, 俊郎 and 柏木, 厚典}, issue = {1}, journal = {滋賀医科大学雑誌}, month = {Feb}, note = {Departmental Bulletin Paper, We developed molecular contrast agent for mouse pancreatic beta-cells. Peptide targeting beta-cells have been selected byphage display method. For MR contrast, we conjugated the peptide probe with superparamagnetic iron oxide. After tail veininjection of the agent, MR images of normal and streptozotocin-induced diabetic mice were acquired by 7T MR scanner. Thepancreas of the normal mice was well enhanced 30 to 60 minutes after the injection, but the pancreas of diabetic mice was not.These results indicate that the contrast agent has effectively enhance pancreatic beta-cells and has potential for clinical use.}, pages = {a08--a10}, title = {ファージディスプレイ法を用いた分子標的造影剤の開発 : マウス膵臓のβ細胞の造影(第9回基礎・臨床融合の学内共同研究発表会)(抄録)}, volume = {26}, year = {2013} }