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Fut9 Deficiency Causes Abnormal Neural Development in the Mouse Cerebral Cortex and Retina.
http://hdl.handle.net/10422/00013365
http://hdl.handle.net/10422/0001336501e532a6-298d-40de-8f79-626280dd6f81
名前 / ファイル | ライセンス | アクション |
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s11064-022-03651-8 (11.6 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-07-04 | |||||
タイトル | ||||||
タイトル | Fut9 Deficiency Causes Abnormal Neural Development in the Mouse Cerebral Cortex and Retina. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Corticothalamic projection neurons | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Fucosyltransferase | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Migration | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Neural stem cells | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Retinal precursor cells | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
ABDULLAH, Asmaa Binti
× ABDULLAH, Asmaa Binti× HAYASHI, Yoshitaka× MORIMURA, Naoko× KUMAR, Akhilesh× IKENAKA, Kazuhiro× TOGAYACHI, Akira× NARIMATSU, Hisashi× HITOSHI, Seiji |
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著者別名 |
林, 義剛
× 林, 義剛× 守村, 直子× 等, 誠司 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | α1,3-Fucosyltransferase 9 (Fut9) is responsible for the synthesis of Lewis X [LeX, Galβ1-4(Fucα1-3)GlcNAc] carbohydrate epitope, a marker for pluripotent or multipotent tissue-specific stem cells. Although Fut9-deficient mice show anxiety-related behaviors, structural and cellular abnormalities in the brain remain to be investigated. In this study, using in situ hybridization and immunohistochemical techniques in combination, we clarified the spatiotemporal expression of Fut9, together with LeX, in the brain and retina. We found that Fut9-expressing cells are positive for Ctip2, a marker of neurons residing in layer V/VI, and TLE4, a marker of corticothalamic projection neurons (CThPNs) in layer VI, of the cortex. A birthdating analysis using 5-ethynyl-2'-deoxyuridine at embryonic day (E)11.5, 5-bromo-2'-deoxyuridine at E12.5, and in utero electroporation of a GFP expression plasmid at E14.5 revealed a reduction in the percentage of neurons produced at E11.5 in layer VI/subplate of the cortex and in the ganglion cell layer of the retina in P0 Fut9-/- mice. Furthermore, this reduction in layer VI/subplate neurons persisted into adulthood, leading to a reduction in the number of Ctip2strong/Satb2- excitatory neurons in layer V/VI of the adult Fut9-/- cortex. These results suggest that Fut9 plays significant roles in the differentiation, migration, and maturation of neural precursor cells in the cortex and retina. | |||||
書誌情報 |
en : Neurochemical research 発行日 2022-06-26 |
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出版者 | ||||||
出版者 | Springer Nature | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1573-6903 | |||||
PMID | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 35753011 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1007/s11064-022-03651-8 | |||||
関連名称 | 10.1007/s11064-022-03651-8 | |||||
権利 | ||||||
権利情報 | © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | ||||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal Article |