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Anti-inflammatory roles of interleukin-35 in the pathogenesis of Japanese cedar pollinosis.
http://hdl.handle.net/10422/00013094
http://hdl.handle.net/10422/000130948449d3c5-8dee-402f-80b2-8c657452e6a3
名前 / ファイル | ライセンス | アクション |
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apallergy.2021.11.e34 (4.0 MB)
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This is an Open Access article distributed under the terms of the Creative
Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-10-05 | |||||
タイトル | ||||||
タイトル | Anti-inflammatory roles of interleukin-35 in the pathogenesis of Japanese cedar pollinosis. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Japanese cedar pollinosis | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | IL-35 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Th2 cell | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Group 2 innate lymphoid cell | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | B cell | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
KOUZAKI, Hideaki
× KOUZAKI, Hideaki× ARAI, Yukihiro× NAKAMURA, Keigo× MARUO, Takuya× TOJIMA, Ichiro× SHIMIZU, Shino× YUTA, Atsushi× SHIMIZU, Takeshi |
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著者別名 |
神前, 英明
× 神前, 英明× 中村, 圭吾× 戸嶋, 一郎× 清水, 志乃× 清水, 猛史 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background: Interleukin (IL)-35 has been recently identified as an anti-inflammatory cytokine in allergic inflammation. However, its biological role in the pathogenesis of allergic rhinitis has not been fully elucidated. |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Objective: The purpose of this study was to investigate the anti-inflammatory activity of IL-35 in the pathogenesis of allergic rhinitis in patients with Japanese cedar pollinosis (JCP). |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Methods: Peripheral blood mononuclear cells were collected from healthy controls and JCP patients during the off-season for pollen. Peripheral blood mononuclear cells were incubated with Cry j 1, a major allergen of Japanese cedar pollen and production of IL-5, IL-13, and IL-35 were measured by enzyme-linked immunosorbent assay. Th2 (CD4+ST2+) cells and group 2 innate lymphoid cells were isolated from peripheral blood mononuclear cells of JCP patients, and the inhibitory effects of IL-35 on cell differentiation, proliferation and mRNA expression of IL-5, IL-13, and GATA3 were examined. B cells were also isolated and the effects of IL-35 on total IgE production were examined. |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Results: Cry j 1-induced production of IL-5 and IL-13 was significantly increased in peripheral blood mononuclear cells from JCP patients, whereas Cry j 1-induced IL-35 production was significantly decreased compared with healthy controls. IL-35 significantly inhibited Th2 cell differentiation, group 2 innate lymphoid cell proliferation, and mRNA expression of IL-5, IL-13, and GATA3 in Th2 cells and group 2 innate lymphoid cells. IL-35 also inhibited IgE production from B cells. |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Conclusion: IL-35 is an important anti-inflammatory cytokine in JCP, and its biological roles include the downregulation of Th2 cells and group 2 innate lymphoid cells, and the inhibition of IgE production from B cells. These findings demonstrate that IL-35 may have the potential to exert anti-allergic effects for the treatment of allergic rhinitis. |
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書誌情報 |
en : Asia Pacific allergy 巻 11, 号 3, 発行日 2021-07-21 |
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出版者 | ||||||
出版者 | Asia Pacific Association of Allergy, Asthma and Clinical Immunology | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2233-8276 | |||||
PMID | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 34386410 | |||||
PMCID | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc8331259/ | |||||
関連名称 | PMC8331259 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.5415/apallergy.2021.11.e34 | |||||
関連名称 | 10.5415/apallergy.2021.11.e34 | |||||
権利 | ||||||
権利情報 | © 2021. Asia Pacific Association of Allergy, Asthma and Clinical Immunology. | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | ||||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal Article |