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Neutralizing antibody-dependent and -independent immune responses against SARS-CoV-2 in cynomolgus macaques.
http://hdl.handle.net/10422/00012897
http://hdl.handle.net/10422/00012897850edac3-e1f5-4bfa-bad6-e90714ccf81e
名前 / ファイル | ライセンス | アクション |
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j.virol.2020.12.013 (4.9 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-01-22 | |||||
タイトル | ||||||
タイトル | Neutralizing antibody-dependent and -independent immune responses against SARS-CoV-2 in cynomolgus macaques. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Neutralizing antibody | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Nonhuman primate | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Pneumonia | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | SARS-CoV-2 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Th1 response | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Thrombus | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
ISHIGAKI, Hirohito
× ISHIGAKI, Hirohito× NAKAYAMA, Misako× KITAGAWA, Yoshinori× NGUYEN, Cong Thanh× HAYASHI, Kaori× SHIOHARA, Masanori× GOTOH, Bin× ITOH, Yasushi |
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著者別名 |
石垣, 宏仁
× 石垣, 宏仁× 仲山, 美沙子× 北川, 善紀× 林, 香里× 塩原, 正規× 後藤, 敏× 伊藤, 靖 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We examined the pathogenicity of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in cynomolgus macaques for 28 days to establish an animal model of COVID-19 for the development of vaccines and antiviral drugs. Cynomolgus macaques infected with SARS-CoV-2 showed body temperature rises and X-ray radiographic pneumonia without life-threatening clinical signs of disease. A neutralizing antibody against SARS-CoV-2 and T-lymphocytes producing interferon (IFN)-γ specifically for SARS-CoV-2 N-protein were detected on day 14 in one of three macaques with viral pneumonia. In the other two macaques, in which a neutralizing antibody was not detected, T-lymphocytes producing IFN-γ specifically for SARS-CoV-2 N protein increased on day 7 to day 14, suggesting that not only a neutralizing antibody but also cellular immunity has a role in the elimination of SARS-CoV-2. Thus, because of similar symptoms to approximately 80% of patients, cynomolgus macaques are appropriate to extrapolate the efficacy of vaccines and antiviral drugs for humans. | |||||
書誌情報 |
en : Virology 巻 554, p. 97-105, 発行日 2021-02 |
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出版者 | ||||||
出版者 | Elsevier | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1096-0341 | |||||
PMID | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 33412411 | |||||
PMCID | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7771262/ | |||||
関連名称 | PMC7771262 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1016/j.virol.2020.12.013 | |||||
関連名称 | 10.1016/j.virol.2020.12.013 | |||||
権利 | ||||||
権利情報 | © 2020. Published by Elsevier Inc. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal Article |