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Novel Respiratory Impedance-Based Phenotypes Reflect Different Pathophysiologies in Chronic Obstructive Pulmonary Disease Patients.
http://hdl.handle.net/10422/00012608
http://hdl.handle.net/10422/00012608635224ca-8dbf-42b2-97c3-4a01aaa43fdc
名前 / ファイル | ライセンス | アクション |
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COPD.S224902 (476.7 kB)
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SupplementaryFigure (225.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-01-10 | |||||
タイトル | ||||||
タイトル | Novel Respiratory Impedance-Based Phenotypes Reflect Different Pathophysiologies in Chronic Obstructive Pulmonary Disease Patients. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | COPD | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | emphysema | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | exhalation | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | oscillometry | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | quantitative evaluation | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
MATSUO-KASHIWAGI, Yumiko
× MATSUO-KASHIWAGI, Yumiko× OGAWA, Emiko× SETO-YUKIMURA, Ruriko× RYUJIN, Yasushi× KINOSE, Daisuke× YAMAGUCHI, Masafumi× OSAWA, Makoto× NAGAO, Taishi× KUROSAWA, Hajime× NAKANO, Yasutaka |
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著者別名 |
松尾, 裕美子
× 松尾, 裕美子× 小川, 惠美子× 行村, 瑠里子× 龍神, 慶× 黄瀬, 大輔× 山口, 将史× 大澤, 真× 長尾, 大志× 中野, 恭幸 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Purpose: The forced oscillation technique (FOT) is a non-invasive method to measure respiratory impedance, the respiratory resistance (Rrs) and reactance (Xrs). The disease probability measure (DPM) is a useful computed tomography (CT) imaging variable for the assessment of gas trapping and emphysema in patients with chronic obstructive pulmonary disease (COPD) using pairs of inspiratory and expiratory CT images. We aimed to develop FOT-based phenotypes and determine whether the phenotypes and their imaging characteristics could facilitate the understanding of COPD pathophysiology. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Patients and methods: FOT and spirometry were examined in 164 COPD patients and 22 non-COPD smokers. COPD patients were divided into four FOT-based phenotypes (NL, normal group; RD, resistance-dominant group; XD, reactance-dominant group; and MIX, mixed group) based on the 3rd quartile values of R5 (Rrs at 5Hz) and X5 (Xrs at 5Hz) in the non-COPD group. The emphysematous lesions and the airway lesions were quantitatively assessed in CT images by low attenuation volume and the square root of the wall area of a hypothetical airway with an internal perimeter of 10 mm (√Aaw at Pi10), respectively. DPM imaging analysis was also performed in 131 COPD patients. We investigated the differences in COPD parameters between the FOT-based phenotypes. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Results: √Aaw at Pi10 were significantly higher in the RD, XD, and MIX groups than in the NL group. The XD group showed lower pulmonary function and higher dyspnea scores than the RD group. No significant changes in DPM values were observed between the RD and the NL groups. The gas-trapping area was significantly higher in the XD group than in the NL group. The MIX group showed the highest dyspnea score, most emphysematous lesions, and the lowest forced expiratory volume in 1 s % predicted value. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Conclusion: The FOT-based phenotyping may be useful to assess pathophysiological changes of COPD with CT assessments. | |||||
書誌情報 |
en : International journal of chronic obstructive pulmonary disease 巻 14, p. 2971-2977, 発行日 2019-12-20 |
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出版者 | ||||||
出版者 | DOVE Medical Press | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1176-9106 | |||||
PMID | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 31908445 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.2147/copd.s224902 | |||||
関連名称 | 10.2147/COPD.S224902 | |||||
権利 | ||||||
権利情報 | © 2019 Matsuo et al. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal Article |