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Ranibizumab and Aflibercept: Intraocular Pharmacokinetics and Their Effects on Aqueous VEGF Level in Vitrectomized and Nonvitrectomized Macaque Eyes.
http://hdl.handle.net/10422/00012474
http://hdl.handle.net/10422/000124744b98f884-c27b-4f1b-bb8b-23d76362cea6
名前 / ファイル | ライセンス | アクション |
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iovs.15-17279.pdf (537.2 kB)
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Copyright 2015 The Association for Research in Vision and Ophthalmology, Inc.
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-12-04 | |||||
タイトル | ||||||
タイトル | Ranibizumab and Aflibercept: Intraocular Pharmacokinetics and Their Effects on Aqueous VEGF Level in Vitrectomized and Nonvitrectomized Macaque Eyes. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | VEGF | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ranibizumab | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | aflibercept | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Niwa, Yuichi
× Niwa, Yuichi× KAKINOKI, Masashi× 澤田, 智子× Wang, Xiying× OHJI, Masahito |
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著者別名 |
丹羽, 雄一
× 丹羽, 雄一× 柿木, 雅志× 澤田, 智子× Wang, Xiying× 大路, 正人 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We evaluated the pharmacokinetics of intravitreally injected ranibizumab and aflibercept, and their effects on VEGF in the aqueous humor of vitrectomized and nonvitrectomized macaque eyes. Intravitreal ranibizumab (IVR; 0.5 mg/50 μL) or intravitreal aflibercept (IVA; 2 mg/50 μL) was injected into the previously vitrectomized right eyes of three macaques and nonvitrectomized right eyes of three macaques. The left eyes served as controls (nonvitrectomized, noninjected). Aqueous humor was obtained from both eyes just before injection and on days 1 and 3, and weeks 1 to 8 after IVR and IVA. The ranibizumab, aflibercept, and VEGF concentrations were measured using enzyme-linked immunosorbent assays. The half-lives in aqueous humor of nonvitrectomized and vitrectomized eyes were, respectively, 2.3 and 1.4 days for ranibizumab, and 2.2 and 1.5 days for aflibercept. Concentration of VEGF was decreased below the limit of detection (LOD) by IVR for 3 weeks in nonvitrectomized eyes and 1 week in vitrectomized eyes, respectively, and by IVA for 6 weeks in nonvitrectomized eyes and 4 weeks in vitrectomized eyes, respectively. In the untreated control eyes, the ranibizumab and aflibercept concentrations were below the LOD, and the VEGF aqueous concentrations remained unchanged after IVR and decreased for 3 days after IVA. Intravitreally injected ranibizumab and aflibercept have similar half-lives in aqueous humor and shorter half-lives in vitrectomized eyes. Compared to IVR, IVA suppresses VEGF level for a longer time period. |
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書誌情報 |
Investigative Ophthalmology & Visual Science 巻 56, 号 11, p. 6501-6505, 発行日 2015-10 |
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出版者 | ||||||
出版者 | Louis, Mosby | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1552-5783 | |||||
PMID | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 26447985 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1167/iovs.15-17279 | |||||
権利 | ||||||
権利情報 | Copyright 2015 The Association for Research in Vision and Ophthalmology, Inc. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal Article |