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Assessment of Sunitinib-Induced Toxicities and Clinical Outcomes Based on Therapeutic Drug Monitoring of Sunitinib for Patients With Renal Cell Carcinoma.
http://hdl.handle.net/10422/10933
http://hdl.handle.net/10422/10933627a46b4-84c0-4de9-9dc7-544071ed2e38
名前 / ファイル | ライセンス | アクション |
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j.clgc.2015.01.007.pdf (493.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2016-02-18 | |||||
タイトル | ||||||
タイトル | Assessment of Sunitinib-Induced Toxicities and Clinical Outcomes Based on Therapeutic Drug Monitoring of Sunitinib for Patients With Renal Cell Carcinoma. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Sunitinib | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Renal cell carcinoma | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Pharmacokinetics | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Therapeutic drug monitoring | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
NODA, Satoshi
× NODA, Satoshi× OTSUJI, Takashi× BABA, Masato× YOSHIDA, Tetsuya× KAGEYAMA, Susumu× OKAMOTO, Keisei× OKADA, Yusaku× KAWAUCHI, Akihiro× ONISHI, Hiroyuki× HIRA, Daiki× MORITA, Shin-ya× TERADA, Tomohiro |
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著者別名 |
野田, 哲史
× 野田, 哲史× 吉田, 哲也× 影山, 進× 河内, 明宏× 平, 大樹× 森田, 真也× 寺田, 智祐 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background: Sunitinib has been approved for the treatment of metastatic renal cell carcinoma (RCC). Sunitinib pharmacokinetics shows a large interpatient variability. |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Patients and methods: A retrospective, observational clinical study of 21 patients with RCC was performed. Sunitinib was administered for 4 weeks of a 6-week cycle for the first cycle. We evaluated the association of sunitinib-induced toxicities and clinical outcomes with the trough total sunitinib concentration in a steady state during the first cycle. |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Results: The median total sunitinib concentration was 91.8 ng/mL (range, 49.8-205 ng/mL). There was an association between total sunitinib concentration and the severity of thrombocytopenia, anorexia, and fatigue. Patients with ≥ 100 ng/mL total sunitinib (n = 8), compared with patients with < 100 ng/mL (n = 13), had a greater incidence of Grade ≥ 3 toxicities (6 patients [75.0%] vs. 3 patients [23.1%]). Patients with < 100 ng/mL total sunitinib had significantly longer time to treatment failure (TTF) and progression-free survival (PFS) time than patients with ≥ 100 ng/mL (median TTF, 590 vs. 71 days; P = .04; median PFS, 748 vs. 238 days; P = .02). |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Conclusion: Results of this study suggest that therapeutic drug monitoring of sunitinib could be useful for avoiding severe toxicities. Dose reduction might be needed, especially when the total sunitinib concentration is ≥ 100 ng/mL, to avoid unnecessary early discontinuation of treatment. |
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書誌情報 |
en : Clinical genitourinary cancer 巻 13, 号 4, p. 350-358, 発行日 2015-08 |
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出版者 | ||||||
出版者 | Elsevier | |||||
PMID | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 25701374 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1016/j.clgc.2015.01.007 | |||||
関連名称 | 10.1016/j.clgc.2015.01.007 | |||||
権利 | ||||||
権利情報 | © 2015 Elsevier Inc. All rights reserved. | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | ||||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal Article |