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ペプチダーゼは白内障形成に重要な役割を果たす : 朱宮白内障ラット眼球におけるペプチダーゼの免疫組織化学的検討
http://hdl.handle.net/10422/119
http://hdl.handle.net/10422/119f935a272-e411-4d76-bfba-142c257d6e0d
名前 / ファイル | ライセンス | アクション |
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jsums17p015.pdf (999.5 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2016-04-12 | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | ペプチダーゼは白内障形成に重要な役割を果たす : 朱宮白内障ラット眼球におけるペプチダーゼの免疫組織化学的検討 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Peptidases play an important role in cataractogenesis : an immunohistochemical study on lenses derived from Shumiya cataract rats | |||||
タイトル | ||||||
言語 | ja-Kana | |||||
タイトル | ペプチダーゼ ハ ハクナイショウ ケイセイ ニ ジュウヨウナ ヤクワリ ヲ ハタス : シュミヤ ハクナイショウ ラット ガンキュウ ニ オケル ペプチダーゼ ノ メンエキ ソシキ カガクテキ ケントウ | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
張, 輝
× 張, 輝× 山本, 好男× 朱宮, 正剛× 国松, 己歳× 西, 克治× 大久保, 岩男× 可児, 一孝 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The role of proteolytic enzymes in Shumiya cataract rats (SCR) in alterations to lens proteins duringcataract formation was immunohistochemically studied using antibodies against exopeptidases, such aslysosomal dipeptidyl peptidase II (DPP II), cytosolic DPP III and alanyl aminopeptidase (AAP-S), membraneboundAAP-N, and against cytosolic endopeptidases such as μ- and m-calpains, and 20S proteasome. αBCrystallinwas detected as a proteolytic marker in the lenses. The reactivity of these peptidases increasedin lens fibres with age in SCRs, but that of αB-crystallin decreased. No reactivity against exo- and endopeptidaseswas shown in the lens perinuclear region of lenses of control rats at all ages and in SCRs at 8 and 10weeks of age, but an intensive reactivity against these peptidases was observed in the lens perinuclear regionof lenses in SCRs at 12 and 14 weeks of age. AAP-N was feebly detected in the lens epithelium and fibresof both types of rat at all weeks of age. These findings indicate that these exo- and endopeptidases, exceptfor AAP-N, are thought to kinetically induce lens opacification during cataract formation in SCRs through the intracellular turnover of lens proteins. | |||||
言語 | en | |||||
書誌情報 |
ja : 滋賀医科大学雑誌 巻 17, p. 15-28, 発行日 2002-02 |
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出版者 | ||||||
言語 | ja | |||||
出版者 | 滋賀医科大学雑誌刊行会 | |||||
NCID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN10044327 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |