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Ketone bodies : A double-edged sword for mammalian life span.
http://hdl.handle.net/10422/00013569
http://hdl.handle.net/10422/00013569bbb5f9b6-044b-4390-a8e0-1a1053369b69
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
acel.13833 (871.2 kB)
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This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2023-05-31 | |||||
| タイトル | ||||||
| タイトル | Ketone bodies : A double-edged sword for mammalian life span. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Hmgcs2 | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | ketone body | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | longevity | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | low-carbohydrate ketogenic diet | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
TOMITA, Issei
× TOMITA, Issei× TSURUTA, Hiroaki× YASUDA-YAMAHARA, Mako× YAMAHARA, Kosuke× KUWAGATA, Shogo× TANAKA-SASAKI, Yuki× KANASAKI-CHIN, Masami× FUJITA, Yukihiro× NISHI, Eiichiro× KATAGIRI, Hideki× MAEGAWA, Hiroshi× KUME, Shinji |
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| 著者別名 |
富田, 一聖
× 富田, 一聖× 霍田, 裕明× 山原, 真子× 山原, 康佑× 桑形, 尚吾× 佐々木, 裕紀× 金崎, 雅美× 藤田, 征弘× 西, 英一郎× 前川, 聡× 久米, 真司 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Accumulating evidence suggests health benefits of ketone bodies, and especially for longevity. However, the precise role of endogenous ketogenesis in mammalian life span, and the safety and efficacy of the long-term exogenous supplementation of ketone bodies remain unclear. In the present study, we show that a deficiency in endogenous ketogenesis, induced by whole-body Hmgcs2 deletion, shortens life span in mice, and that this is prevented by daily ketone body supplementation using a diet containing 1,3-butanediol, a precursor of β-hydroxybutyrate. Furthermore, feeding the 1,3-butanediol-containing diet from early in life increases midlife mortality in normal mice, but in aged mice it extends life span and prevents the high mortality associated with atherosclerosis in ApoE-deficient mice. By contrast, an ad libitum low-carbohydrate ketogenic diet markedly increases mortality. In conclusion, endogenous ketogenesis affects mammalian survival, and ketone body supplementation may represent a double-edged sword with respect to survival, depending on the method of administration and health status. | |||||
| 書誌情報 |
en : Aging cell 発行日 2023-04-14 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1474-9726 | |||||
| PMID | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 37060184 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1111/acel.13833 | |||||
| 関連名称 | 10.1111/acel.13833 | |||||
| 権利 | ||||||
| 権利情報 | © 2023 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd. | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Journal Article | |||||
