WEKO3
アイテム
Increased Cellular Expression of Interleukin-6 in Patients With Ossification of the Posterior Longitudinal Ligament.
http://hdl.handle.net/10422/00013531
http://hdl.handle.net/10422/00013531a9fa76e5-ff21-4abe-8524-5853685c62f1
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2023-04-12 | |||||
| タイトル | ||||||
| タイトル | Increased Cellular Expression of Interleukin-6 in Patients With Ossification of the Posterior Longitudinal Ligament. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
SAITO, Hideki
× SAITO, Hideki× YAYAMA, Takafumi× MORI, Kanji× KUMAGAI, Kosuke× FUJIKAWA, Hitomi× CHOSEI, Yuya× IMAI, Shinji |
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| 著者別名 |
齋藤, 英貴
× 齋藤, 英貴× 彌山, 峰史× 森, 幹士× 熊谷, 康佑× 藤川, ひとみ× 蝶勢, 友也× 今井, 晋二 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Study design: We performed histologic, immunohistochemical, immunoblot examination and suspension array analyses of cytokine expression in cultured cells derived from human cervical ossification of the posterior longitudinal ligament (OPLL). |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objective: To determine the roles of interleukin-6 (IL-6) during the maturation of osteoblasts and chondrocytes associated with the development of OPLL. |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Summary of background data: Ectopic OPLL affects ~3% of the general population, with a higher incidence in Asian ethnic groups. Alterations in cytokine profiles may influence osteoblast differentiation, but the mechanisms and signaling pathways associated with the ossification process remain unclear. |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Methods: Samples were collected from 14 patients with OPLL who had undergone spinal surgery and seven with cervical spondylotic myelopathy without OPLL. Tissue sections were used for histologic and immunohistochemical studies, and primary cells from ligamentum samples were used for cytokine array and immunoblotting. A suspension array was used to measure the concentrations of 27 inflammatory cytokines or growth factors. |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Results: Suspension array and immunoblot analyses revealed significantly elevated levels of IL-6 in OPLL patients. Alterations in IL-6 concentrations were found to alter the expression of the genes Sox9 , Runx2 , and SIRT1 . In addition, immunohistochemical analysis revealed that these factors are present in mesenchymal cells within the degenerative portion of the ligament matrix that is adjacent to the ossification front. |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Conclusions: IL-6 plays a profound role in the osteoblast differentiation process along with the induction of chondrocyte hypertrophy and cell apoptosis in the early stages of ossification in OPLL. These changes in cytokine profiles are essential factors for regulation of the ectopic ossified plaque in OPLL. |
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| 書誌情報 |
en : Spine 巻 48, 号 6, p. E78-E86, 発行日 2023-03-15 |
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| 出版者 | ||||||
| 出版者 | Wolters Kluwer Health | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1528-1159 | |||||
| PMID | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 36729990 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1097/brs.0000000000004557 | |||||
| 関連名称 | 10.1097/brs.0000000000004557 | |||||
| 権利 | ||||||
| 権利情報 | © 2022 Wolters Kluwer Health, Inc. All rights reserved. | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Journal Article | |||||
