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Bovine lactoferrin suppresses inflammatory cytokine expression in endometrial stromal cells in chronic endometritis.
http://hdl.handle.net/10422/00013472
http://hdl.handle.net/10422/0001347292ad912e-0bc1-470f-a1f1-6f4cd71da46b
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
j.jri.2022.103761 (693.5 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2022-12-14 | |||||
| タイトル | ||||||
| タイトル | Bovine lactoferrin suppresses inflammatory cytokine expression in endometrial stromal cells in chronic endometritis. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Chronic endometritis | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Endometrial stromal cells | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Lactoferrin | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
NAKAMURA, Akiko
× NAKAMURA, Akiko× KIMURA, Fuminori× TSUJI, Shunichiro× HANADA, Tetsuro× TAKEBAYASHI, Akie× TAKAHASHI, Akimasa× KITAZAWA, Jun× MORIMUNE, Aina× AMANO, Tsukuru× KUSHIMA, Ryoji× MURAKAMI, Takashi |
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| 著者別名 |
中村, 暁子
× 中村, 暁子× 木村, 文則× 辻, 俊一郎× 花田, 哲郎× 竹林, 明枝× 高橋, 顕雅× 北澤, 純× 森宗, 愛菜× 天野, 創× 九嶋, 亮治× 村上, 節 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Chronic endometritis (CE) is a type of chronic inflammation in the endometrium that is associated with infertility, which is primarily due to implantation failure. Antibiotics are the most common treatment for CE. However, some patients with CE are resistant to antibiotic treatment, while others refuse this treatment. Therefore, we focused on lactoferrin (Lf), which exhibits antimicrobial and anti-inflammatory properties, and studied its effect on inflammation in endometrial stromal cells (ESCs) from patients with CE. Endometrial tissue was collected from patients with CE, and ESCs were isolated and cultured. When ESCs were cultured with bovine lactoferrin (bLf: 1 mg/mL), the mRNA expression of TNF-α (p < 0.05) and IL-1β (p < 0.01) was significantly decreased compared with that in cells cultured without bLf. The level of TNF-α protein in the culture medium was significantly decreased (p < 0.01), while that of IL-1β was also decreased, but not significantly (p < 0.10), when 1 mg/mL of bLf was added to the culture medium. When more inflammation was induced artificially by adding 0.1 ng/mL of TNF-αto ESCs, the addition of bLf (1 mg/mL) to ESCs decreased IL-6 and IL-1β mRNA expression to levels similar to those in ESCs without TNF-α treatment. Furthermore, it was revealed that the actions of bLf are mediated by the AKT and MAPK intracellular signaling pathways, which are mechanisms by which the increase in TNF-α-induced cytokine expression is suppressed in ESCs. bLf suppresses the expression of inflammatory cytokines in human ESCs and may be a new therapeutic candidate for CE. | |||||
| 書誌情報 |
en : Journal of reproductive immunology 巻 154, 発行日 2022-12 |
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| 出版者 | ||||||
| 出版者 | Elsevier Ireland Ltd | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1872-7603 | |||||
| PMID | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 36403531 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1016/j.jri.2022.103761 | |||||
| 関連名称 | 10.1016/j.jri.2022.103761 | |||||
| 権利 | ||||||
| 権利情報 | © 2022 Elsevier B.V. All rights reserved. | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Journal Article | |||||
