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Molecular Dissection of TDP-43 as a Leading Cause of ALS/FTLD
http://hdl.handle.net/10422/00013457
http://hdl.handle.net/10422/00013457675975f2-d938-43ca-a18b-0922b6e20f6e
名前 / ファイル | ライセンス | アクション |
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ijms232012508 (5.9 MB)
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This is an open access article distributed under the Creative Commons
Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2022-11-21 | |||||
タイトル | ||||||
タイトル | Molecular Dissection of TDP-43 as a Leading Cause of ALS/FTLD | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | TDP-43 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | RNA metabolism | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | aggregation | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | phase separation | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | neurodegenerative diseases | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | ALS | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | FTLD | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
TAMAKI, Yoshitaka
× TAMAKI, Yoshitaka× URUSHITANI, Makoto |
|||||
著者別名 |
漆谷, 真
× 漆谷, 真 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | TAR DNA binding protein 43 (TDP-43) is a DNA/RNA binding protein involved in pivotal cellular functions, especially in RNA metabolism. Hyperphosphorylated and ubiquitinated TDP-43-positive neuronal cytoplasmic inclusions are identified in the brain and spinal cord in most cases of amyotrophic lateral sclerosis (ALS) and a substantial proportion of frontotemporal lobar degeneration (FTLD) cases. TDP-43 dysfunctions and cytoplasmic aggregation seem to be the central pathogenicity in ALS and FTLD. Therefore, unraveling both the physiological and pathological mechanisms of TDP-43 may enable the exploration of novel therapeutic strategies. This review highlights the current understanding of TDP-43 biology and pathology, describing the cellular processes involved in the pathogeneses of ALS and FTLD, such as post-translational modifications, RNA metabolism, liquid-liquid phase separation, proteolysis, and the potential prion-like propagation propensity of the TDP-43 inclusions. | |||||
書誌情報 |
en : International Journal of Molecular Sciences |
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出版者 | ||||||
出版者 | MDPI | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1661-6596 | |||||
PMID | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 36293362 | |||||
PMCID | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc9604209/ | |||||
関連名称 | PMC9604209 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.3390/ijms232012508 | |||||
関連名称 | 10.3390/ijms232012508 | |||||
権利 | ||||||
権利情報 | © 2022 by the authors. Licensee MDPI, Basel, Switzerland. | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal Article |