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Analysis of Risk Factors for High-dose Cisplatin-induced Renal Impairment in Head and Neck Cancer Patients
http://hdl.handle.net/10422/00013424
http://hdl.handle.net/10422/00013424f5ba6d92-b8c2-48b5-be0d-c5686316e3c8
名前 / ファイル | ライセンス | アクション |
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invivo.12982 (562.4 kB)
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This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY-NC-ND) 4.0 international license
(https://creativecommons.org/licenses/by-nc-nd/4.0). |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-10-13 | |||||
タイトル | ||||||
タイトル | Analysis of Risk Factors for High-dose Cisplatin-induced Renal Impairment in Head and Neck Cancer Patients | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | cisplatin | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | chemoradiotherapy | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | renal impairment | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | head and neck cancer | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
KOIDE, Hiroyoshi
× KOIDE, Hiroyoshi× NODA, Satoshi× OKUNUKI, Yumi× OWAKI, Shigehiro× SHIMIZU, Takeshi× TERADA, Tomohiro× MORITA, Shin-ya |
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著者別名 |
小出, 博義
× 小出, 博義× 野田, 哲史× 奥貫, 裕美× 大脇, 成広× 清水, 猛史× 森田, 真也 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background/Aim: Concurrent chemoradiotherapy with high-dose cisplatin (CDDP-RT) is the standard therapy for advanced head and neck cancer; however, due to CDDP-induced renal impairment, dose reduction or discontinuation is frequently required. Therefore, the identification of risk factors for renal impairment is of importance to improve the efficacy and safety of CDDP-RT. |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Patients and Methods: We retrospectively investigated risk factors for renal impairment in advanced head and neck cancer patients receiving CDDP-RT. Renal impairment was defined as a >25% decrease from baseline in estimated glomerular filtration rate within 14 days after CDDP administration in the first cycle. |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Results: Of the 82 patients analyzed in this study, 21 (26%) patients developed renal impairment. Multivariate logistic regression analysis showed that concomitant use of a calcium channel blocker or lower hemoglobin levels significantly contributed to the increased risk of CDDP-induced renal impairment (odds ratio=3.60, 95% confidence interval=1.04-12.40; odds ratio=0.71, 95% confidence interval=0.50-0.99, respectively), while concomitant use of proton pump inhibitors was a factor associated with a decreased risk of CDDP-induced renal impairment (odds ratio=0.20, 95% confidence interval=0.04-0.86). |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Conclusion: Renal function of patients receiving calcium channel blocker or patients with lower hemoglobin levels should be monitored cautiously when receiving CDDP-RT. |
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書誌情報 |
en : In Vivo 巻 36, 号 5, p. 2465-2472, 発行日 2022-09-07 |
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出版者 | ||||||
出版者 | International Institute of Anticancer Research | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1791-7549 | |||||
PMID | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 36099135 | |||||
PMCID | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc9463891/ | |||||
関連名称 | PMC9463891 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.21873/invivo.12982 | |||||
関連名称 | 10.21873/invivo.12982 | |||||
権利 | ||||||
権利情報 | © 2022, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved. | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | ||||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal Article |