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Early P2Y 12 Inhibitor Single Antiplatelet Therapy for High-Bleeding Risk Patients After Stenting - PENDULUM Mono 24-Month Analysis
http://hdl.handle.net/10422/00013409
http://hdl.handle.net/10422/0001340996464638-563c-41b7-9c02-46349589e116
名前 / ファイル | ライセンス | アクション |
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circj.CJ-21-1004 (1.7 MB)
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This article is licensed under a Creative Commons [Attribution-
NonCommercial-NoDerivatives 4.0 International] license. https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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circj.CJ-21-1004_Supplementary Files (626.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-09-20 | |||||
タイトル | ||||||
タイトル | Early P2Y 12 Inhibitor Single Antiplatelet Therapy for High-Bleeding Risk Patients After Stenting - PENDULUM Mono 24-Month Analysis | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Bleeding risk | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Japan | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Percutaneous coronary intervention | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Prasugrel | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Single antiplatelet therapy | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
NAKAGAWA, Yoshihisa
× NAKAGAWA, Yoshihisa× KADOTA, Kazushige× NAKAO, Koichi× SHITE, Junya× YOKOI, Hiroyoshi× KOZUMA, Ken× TANABE, Kengo× AKASAKA, Takashi× SHINKE, Toshiro× UENO, Takafumi× HIRAYAMA, Atsushi× UEMURA, Shiro× IIJIMA, Raisuke× HARADA, Atsushi× KURODA, Takeshi× TAKITA, Atsushi× MURAKAMI, Yoshitaka× SAITO, Shigeru× NAKAMURA, Masato |
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著者(ヨミ) |
中川, 義久
× 中川, 義久 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background: In PENDULUM mono, Japanese patients with high bleeding risk (HBR) received short-term dual antiplatelet therapy (DAPT) followed by single antiplatelet therapy (SAPT) with prasugrel after percutaneous coronary intervention (PCI). One-year data from PENDULUM mono showed better outcomes with prasugrel monotherapy after short-term DAPT compared with matched patients in the PENDULUM registry with longer DAPT durations according to guidelines at that time. This study presents 2-year results.Methods and Results: We compared 24-month data from PENDULUM mono (n=1,107; de-escalation strategy group) and the PENDULUM registry (n=2,273; conventional strategy group); both were multicenter, non-interventional, prospective registry studies, using the inverse probability of treatment weighting (IPTW) method. In the PENDULUM mono group, the cumulative incidence of clinically relevant bleeding (CRB) at 24 months post-PCI (primary endpoint) was 6.8%, and that of major adverse cardiac and cerebrovascular events (MACCE) was 8.9%. After IPTW adjustment, the cumulative incidence of CRB was 5.8% and 7.2% in PENDULUM mono and the PENDULUM registry, respectively (hazard ratio [HR] 0.77; 95% confidence interval [CI] 0.57-1.04; P=0.086), and that of MACCE was 8.0% and 9.5%, respectively (HR 0.77; 95% CI 0.59-1.01; P=0.061). |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Conclusions: Japanese PCI patients with HBR prescribed prasugrel SAPT after short-term DAPT had a lower ischemic event risk than those prescribed long-term DAPT, and this was particularly relevant for ischemic events after 1 year. |
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書誌情報 |
en : Circulation journal : official journal of the Japanese Circulation Society 巻 86, 号 9, p. 1352-1361, 発行日 2022 |
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出版者 | ||||||
出版者 | The Japanese Circulation Society | |||||
別言語の出版者 | ||||||
出版者 | 日本循環器学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1347-4820 | |||||
PMID | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 35584932 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1253/circj.cj-21-1004 | |||||
関連名称 | 10.1253/circj.cj-21-1004 | |||||
権利 | ||||||
権利情報 | © 2022, THE JAPANESE CIRCULATION SOCIETY | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | ||||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal Article |