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Ambient Temperature Is Correlated With the Severity of Neonatal Hypoxic-Ischemic Brain Injury via Microglial Accumulation in Mice.
http://hdl.handle.net/10422/00013370
http://hdl.handle.net/10422/0001337091d192ee-9fe2-4232-9624-7a1dd6053f51
名前 / ファイル | ライセンス | アクション |
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fped.2022.883556 (3.1 MB)
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This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or
reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-07-14 | |||||
タイトル | ||||||
タイトル | Ambient Temperature Is Correlated With the Severity of Neonatal Hypoxic-Ischemic Brain Injury via Microglial Accumulation in Mice. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | neonatal | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | mouse-model | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | brain injury | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | hypoxic-ischemic encephalopathy | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | temperature | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | behavioral changes | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | cerebral volume loss | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | microglia | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
ZEN, Rika
× ZEN, Rika× TERASHIMA, Tomoya× TSUJI, Shunichiro× KATAGI, Miwako× OHASHI, Natsuko× NOBUTA, Yuri× HIGUCHI, Asuka× KANAI, Hirohiko× MURAKAMI, Takashi× KOJIMA, Hideto |
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著者別名 |
全, 梨花
× 全, 梨花× 寺島, 智也× 辻, 俊一郎× 樫, 美和子× 大橋, 夏子× 信田, 侑里× 樋口, 明日香× 金井, 裕彦× 村上, 節× 小島, 秀人 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background: The pathophysiology of neonatal hypoxic-ischemic encephalopathy (HIE) has been studied in several rodent models to develop novel treatments. Although it is well known that high ambient temperature results in severe HIE, the effect of subtle changes in ambient temperature during a hypoxic-ischemic (HI) insult has not been studied. Therefore, in order to clarify the difference of pathophysiological change among the HIE models due to the influence of small changes in chamber temperature, three-step gradual change of 0.5°C each were prepared in ambient temperature during hypoxic exposure. |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Methods: Blood flow in the left common carotid artery (CCA) of neonatal mice was interrupted using bipolar electronic forceps under general and local anesthesia. The mice were subsequently subjected to 10% hypoxic exposure for 50 min at 36.0, 36.5, or 37.0°C. A control group was also included in the study. The size of the striatum and hippocampus and the volume reduction rate of the hemisphere in the section containing them on the ischemic side were evaluated using microtubule associated protein 2 (MAP2) immunostaining. The accumulation of Iba1-positive cells was investigated to assess inflammation. Additionally, rotarod and open-field tests were performed 2 weeks after HI insult to assess its effect on physiological conditions. |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Results: MAP2 staining revealed that the higher the temperature during hypoxia, the more severe the volume reduction rate in the hemisphere, striatum, and hippocampus. The number of Iba1-positive cells in the ipsilateral lesion gradually increased with increasing temperature, and there was a significant difference in motor function in the 36.5 and 37.0°C groups compared with the sham group. In the open-field tests, there was a significant decrease in performance in the 37.0°C groups compared with the 36.0°C and sham groups. |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Conclusions: Even a small gradual change of 0.5°C produced a significant difference in pathological and behavioral changes and contributed to the accumulation of Iba1-positive cells. The arrangement of ambient temperature is useful for creating a rodent model with the appropriate severity of the targeted neuropsychological symptoms to establish a novel therapy for HIE. |
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書誌情報 |
en : Frontiers in Pediatrics 発行日 2022-05-06 |
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出版者 | ||||||
出版者 | Frontiers Media SA | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2296-2360 | |||||
PMID | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 35601427 | |||||
PMCID | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc9120824/ | |||||
関連名称 | PMC9120824 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.3389/fped.2022.883556 | |||||
関連名称 | 10.3389/fped.2022.883556 | |||||
権利 | ||||||
権利情報 | © 2022 Zen, Terashima, Tsuji, Katagi, Ohashi, Nobuta, Higuchi, Kanai, Murakami and Kojima. | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | ||||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal Article |