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Differential Association of Serum n-3 Polyunsaturated Fatty Acids with Various Cerebrovascular Lesions in Japanese Men.
http://hdl.handle.net/10422/00013304
http://hdl.handle.net/10422/00013304a2ef9896-a0cd-4386-885e-85b9d4822dad
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
000524243 (158.4 kB)
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This is an Open Access article licensed under the Creative Commons
Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense), applicable to the online version of the article only. Usage and distribution for commercial purposes requires written permission. |
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2022-05-25 | |||||
| タイトル | ||||||
| タイトル | Differential Association of Serum n-3 Polyunsaturated Fatty Acids with Various Cerebrovascular Lesions in Japanese Men. | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Fatty acids | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Cerebrovascular disease | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Epidemiology | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 著者 |
KONDO, Keiko
× KONDO, Keiko× ARIMA, Hisatomi× FUJIYOSHI, Akira× SEKIKAWA, Akira× KADOTA, Aya× HISAMATSU, Takashi× TORII, Sayuki× SHIINO, Akihiko× MORINO, Katsutaro× MIYAGAWA, Naoko× SEGAWA, Hiroyoshi× WATANABE, Yoshiyuki× MAEGAWA, Hiroshi× NOZAKI, Kazuhiko× MIURA, Katsuyuki× UESHIMA, Hirotsugu |
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| 著者別名 |
近藤, 慶子
× 近藤, 慶子× 有馬, 久富× 藤吉, 朗× 門田, 文× 椎野, 顯彦× 森野, 勝太郎× 瀬川, 裕佳× 渡邉, 嘉之× 前川, 聡× 野﨑, 和彦× 三浦, 克之× 上島, 弘嗣 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: An association between a high intake of marine-derived n-3 polyunsaturated fatty acids (n-3 PUFAs) with a lower risk of coronary heart disease was previously reported. However, the association between n-3 PUFAs and cerebrovascular lesions remains unclear. We evaluated this association in a general-population-based sample of Japanese men. Methods: Participants were community-dwelling men (40-79 years old) living in Kusatsu City, Shiga, Japan. Serum concentrations of n-3 PUFAs, defined as the sum of eicosapentaenoic and docosahexaenoic acids, were measured via gas-liquid chromatography between 2006 and 2008. Magnetic resonance imaging was used to assess cerebrovascular lesions (including intracerebral large-artery stenosis, lacunar infarction, and microbleeds) and white matter lesions between 2012 and 2015. Logistic regression adjusting for conventional cardiovascular risk factors was used to estimate the odds ratio of prevalent cerebrovascular lesions per 1 standard deviation higher serum concentration of n-3 PUFAs. Results: Of a total of 739 men, the numbers (crude prevalence in %) of prevalent cerebral large-artery stenoses, lacunar infarctions, microbleeds, and white matter lesions were 222 (30.0), 162 (21.9), 103 (13.9), and 164 (22.2), respectively. A 1 standard deviation higher concentration of n-3 PUFAs (30.5 μmol/L) was independently associated with lower odds of cerebral large-artery stenosis (multivariable-adjusted odds ratio, 0.80; 95% confidential interval, 0.67-0.97). There were no significant associations of n-3 PUFAs with the other types of lesions. Conclusions: n-3 PUFAs may have protective effects against large-artery stenosis, but not small vessel lesions, in the brain. |
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| 言語 | en | |||||
| 書誌情報 |
en : Cerebrovascular diseases (Basel, Switzerland) 巻 51, 号 6, p. 774-780, 発行日 2022-04-27 |
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| 出版者 | ||||||
| 出版者 | S. Karger AG | |||||
| 言語 | en | |||||
| ISSN | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 1421-9786 | |||||
| PMID | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 35477146 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1159/000524243 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | © 2022 The Author(s). Published by S. Karger AG, Basel. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
